结直肠癌中Kras基因表达与放射治疗的研究进展  

RESEARCH PROGRESS OF KRAS'EXPRESSION AND RADIATION THERAPY IN COLORECTAL CANCER

作　　者：张薇[1] 孙晓革[2] 宝莹娜[2] ZHANG Wei;SUN Xiao-ge;BAO Ying-na(Inner Mongolia Medical University,Hohhot 010059 China)

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特010059 [2]内蒙古医科大学附属医院

出　　处：《内蒙古医科大学学报》2018年第5期532-535,共4页Journal of Inner Mongolia Medical University

基　　金：科技厅应用技术与开发项目(2015)

摘　　要：结直肠癌(Colorectal cancer,CRC)是由抑癌基因和致癌基因的突变积累导致。Kras是原癌基因作用于表皮生长因子(Vascular endothelial growth factor,EGFR)的下游,通过小鼠肉瘤病毒癌基因同源基因B 1(vraf murine sarcoma viral oncogene homolog B1,BRAF)传递信号,触发促分裂原活化的蛋白激酶(mitogenactivated protein kinase,MAPK)通路,诱导细胞增殖,阻止细胞凋亡,引起了55%~60%的CRC.因此,Kras基因的突变与CRC的发生、发展、预后、及其药物治疗与放射治疗有着密不可分的联系,本文对CRC中Kras基因表达与放射治疗的研究进展进行系统的综述。More and more experiments confirmed that,Coloreetal cancer is caused by the accumulation of mutations in tumor suppressor genes and oneogenes. Kras is proto-oneogene acting on the downstream of EGFR. The signal is transmitted by BRAF, which triggers the MAPK pathway, inducing cell proliferation,Preventing apoptosis and causing 55%-60% of CRC.Therefore, the mutation of Kras is closely related to the occurrence, development and prognosis of CRC, as well as drug therapy and radiotherapy.h has become an urgent matter to study CRC in depth. In this article, I will review systematically the research progress of Kras＇ expression and radiotherapy in CRC.

关 键 词：结直肠癌 KRAS 放射治疗 

分 类 号：R739.9[医药卫生—肿瘤]