P-AKT蛋白表达与宫颈癌风险相关性的Meta分析  

Meta-analysis of the correlation between P-AKT protein expression and cervical cancer risk

作　　者：李秀玲 付强[1] 高天明[1] 杨丹鹤 丛丽莉[1] 王俊文[1] LI Xiu-ling;FU Qiang;GA O Tian-ming;YANG Dora-he;CONG Li-li;WANG Jun-wen(Department of Obstetrics and Gynecology,Zhongshan Hospital Affiliated to Dalian University,Liaoning Province,Dalian 116622,China)

机构地区：[1]大连大学附属中山医院妇产科,辽宁大连116622

出　　处：《中国当代医药》2018年第23期26-29,共4页China Modern Medicine

摘　　要：目的系统评价P-AKT蛋白表达与宫颈癌及其不同临床病理特征的相关性。方法计算机检索Cochrane Library、EMBase、Pub Med、维普、读秀及万方和中国知网数据库,查找正式发表关于P-AKT表达与宫颈癌及其临床病理特征相关性的病例随机对照研究,检索日期为建库至2017年12月,提取资料并评价质量后,采用Rev Man 5.3软件进行Meta分析。结果共纳入包括1050例受试者的9项研究,其中宫颈癌患者421例,宫颈上皮内瘤变患者434例,正常宫颈妇女195例。Meta分析结果显示:(1)P-AKT在宫颈癌组与正常宫颈组[OR=25.79,95%CI(11.14,59.70),P<0.00001]、宫颈癌组与CIN组[OR=4.98,95%CI(3.55,7.00),P<0.00001]、CIN组与正常宫颈组[OR=6.53,95%CI(4.14,10.29),P<0.00001]的表达差异均有统计学意义。(2)P-AKT在宫颈癌伴淋巴结转移组与无淋巴结转移组[OR=3.38,95%CI(1.60,7.17),P=0.001]的表达差异有统计学意义;在宫颈癌低分化组与中高分化组[OR=1.03,95%CI(0.49,2.18),P=0.93]、宫颈癌FIGO临床Ⅱ期组与Ⅰ期组[OR=2.09,95%CI(0.90,4.85),P=0.09]的表达差异无统计学意义。结论 P-AKT蛋白表达与宫颈癌具有显著相关性,是宫颈癌潜在诊断和预后指标。Objective To systematically evaluate the correlation of P-AKT protein expression with cervical cancer and its different clinicopathological features. Methods The Cochrane Library, EMBase, Pub Med, VIP, Duxiu, Wanfang and China National Knowledge Internet were retrieved by computer. Case randomized controlled study officially published on the relationship between P-AKT expression and cervical cancer and its clinicopathological features were searched.The search date was from database construction to December 2017. After data were extracted and evaluated its quality,Rev Man 5.3 software was used for meta-analysis. Results A total of 9 studies including 1050 participants were included, there were 421 cases patients with cervical cancer, 434 patients with cervical intraepithelial neoplasia（CIN）, and195 women with normal cervix. Meta-analysis showed that：（1） there were significant differences in the expression of PAKT between cervical cancer and normal cervix group（OR=25.79, 95% CI [11.14, 59.70], P0.00001）, cervical cancer and CIN group（OR=4.98, 95% CI [3.55, 7.00], P0.00001）, and CIN and normal cervix group（OR=6.53, 95% CI [4.14,10.29], P0.00001）.（2） the expression of P-AKT in cervical cancer with lymph node metastasis group and non-metastasis of lymph node group（OR=3.38, 95%CI [1.60, 7.17], P=0.001） was statistically significant, however, there was no great difference was detected between poorly differentiated cervical cancer and moderately-highly differentiated group（OR=1.03, 95% CI [0.49, 2.18], P=0.93） or between clinical phaseⅡ of International Federation of Gynecology and Obstetrics（FIGO） between cervical cancer group and phase I of FIGO in cervical cancer group（OR=2.09, 95% CI [0.90,4.85], P=0.09）. Conclusion The expression of P-AKT protein has significant correlation with cervical cancer and it is a potential diagnostic and prognostic indicator of cervical cancer.

关 键 词：P-AKT 宫颈癌 系统评价 META分析 病例-对照研究 

分 类 号：R737.33[医药卫生—肿瘤]