四联疗法治疗克拉霉素耐药幽门螺杆菌感染的临床效果  

Clinical effect of quadruple therapy in treatment of Clarithromycin resistant Helicobacter pylori infection

作　　者：陈少文 张圳锋 吉明柱 CHEN Shao-wen;ZHANG Zhen-feng;JI Ming-zhue(Department of Internal Medicine,Nan＇ao People＇s Hospital of Dapeng New Area in Shenzhen City,Guangdong Province,Shenzhen 518121,China;Department of gastroenterology,Shekou People＇s Hospital of Nanshan District,Guangdong Province,Shenzhen 512161,China)

机构地区：[1]深圳市大鹏新区南澳人民医院内科,广东深圳518121 [2]深圳市南山区蛇口人民医院消化内科,广东深圳512161

出　　处：《中国当代医药》2018年第23期76-78,共3页China Modern Medicine

摘　　要：目的探讨四联疗法治疗对克拉霉素耐药的幽门螺旋杆菌感染者的临床效果。方法选取2014年2月~2017年2月深圳市大鹏新区南澳人民医院收治的幽门螺杆菌感染患者60例,采用随机数字表法将其分为对照组、研究组,每组30例。对照组采用甲硝唑、奥美拉唑、阿莫西林三联疗法治疗,研究组采用奥美拉唑、枸橼酸铋钾颗粒、阿莫西林、左氧氟沙星四联疗法治疗,比较两组患者的幽门螺杆菌根除率和不良反应总发生率。结果研究组患者的幽门螺杆菌根除率为93.33%(28/30),高于对照组的80%(24/30),差异有统计学意义(χ2=7.6876,P=0.0056)。两组患者不良反应总发生率的比较,差异无统计学意义(P>0.05)。结论临床治疗幽门螺杆菌感染时,建议首选奥美拉唑、阿莫西林、枸橼酸铋钾颗粒、左氧氟沙星四联疗法,可提升幽门螺杆菌根除率,值得进一步推广。Objective To analyze the clinical effect of quadruple therapy in treatment of Clarithromycin resistant Helicobacter pylori infection. Methods Sixty patients with Helicobacter pylori infection admitted to Nan′ ao People′ s Hospital in Dapeng New District, Shenzhen City from February 2014 to February 2017 were selected and divided into control group and study group, by random number table method with 30 cases in each group. The control group was treated with Metronidazole, Omeprazole and Amoxicillin triple therapy, while the study group was treated with Omeprazole, Bismuth Potassium Citrate Granules, Amoxicillin and Levofloxacin triple therapy. The eradication rate of Helicobacter pylori and the total incidence of adverse reactions were compared between the two groups. Results The eradication rate of Helicobacter pylori in the study group was 93.33 %（28/30）, higher than 80 %（24/30） in the control group, the difference was statistically significant（χ2=7.6876, P =0.0056）. There was no significant difference in the total incidence of adverse reactions between the two groups（P〈0.05）. Conclusion In the clinical treatment of Helicobacter pylori infection,Omeprazole, Amoxicillin, Bismuth Potassium Citrate Granules and Levofloxacin are recommended to be the first choice for quadruple therapy, which can improve the eradication rate of helicobacter pylori and is worth further promotion.

关 键 词：幽门螺杆菌 感染 四联疗法 克拉霉素 耐药 

分 类 号：R573[医药卫生—消化系统]