胆道梗阻患者合并胆道感染对肝纤维化及肝功能的影响  

Impact of biliary tract infection on liver fibrosis and liver function in patients with biliary tract obstruction

作　　者：查梅[1] 张伟 刘心怡 周贵[3] 杨靖 罗德军[5] 王钢[6] CHA Mei;ZHANG Wei;LIU Xinyi;ZHOU Gui;YANG Jing;LUO Dejun;WANG Gang(Department of Nosoco-mial Infection Management,Jianyang People＇s Hospital,Jianyang 641400,China)

机构地区：[1]简阳市人民医院感染管理科,四川简阳641400 [2]简阳市人民医院普外科,四川简阳641400 [3]成都市第五人民医院院感科,成都611130 [4]十堰市人民医院(湖北医药学院附属人民医院)肝病研究所,湖北十堰442000 [5]简阳市人民医院骨科,四川简阳641400 [6]简阳市人民医院中心实验室,四川简阳641400

出　　处：《实用医学杂志》2018年第16期2704-2707,共4页The Journal of Practical Medicine

基　　金：四川省卫生和计划生育科研课题资助项目(编号:17PJ122)

摘　　要：目的探讨胆道梗阻患者合并胆道感染对肝纤维化及肝功能的影响。方法收集208例胆道梗阻患者(观察组)和208例健康体检者(对照组)的临床资料,分析观察组中合并胆道感染的发生情况及病原菌构成情况;比较观察组与对照组肝纤维化及肝功能指标的差异;分析胆道梗阻合并胆道感染与肝脏纤维化的关系。结果 208例胆道梗阻患者合并胆道感染的发生率为59.13%,胆道梗阻并发胆道感染患者病原菌的构成中以革兰阴性细菌为主(63.89%);胆道梗阻合并胆道感染患者的肝纤维化四项水平和肝功能指标浓度均高于不合并胆道感染患者及健康体检者(P<0.05);胆道梗阻患者胆道感染与肝脏纤维化之间成正相关(P<0.05)。结论胆道梗阻患者并发胆道感染的概率较高;胆道梗阻并发胆道感染对肝脏的损伤更为严重,临床上应积极且重点关注胆道梗阻并发胆道感染患者。Objective To explore the impact of biliary tract infection on liver fibrosis and liver function in patients with biliary tract obstruction. Methods The data on 416 subjects were collected. Of the subjects, 208 were diagnosed as biliary tract obstruction （study group ） , the others were healthy subjects （control group ）. Incidence of biliary tract infection and the composition of pathogens in the study group were analyzed.Differences in liver fibrosis and liver function indexes between the study group and the control group were compared. The correla- tion between biliary tract obstruction complicated by biliary tract infection and liver fibrosis was analyzed. Results The incidence of biliary tract infection was 59.13% in 208 patients with biliary tract obstruction. The pathogens in biliary tract obstruction patients with biliary tract infection were mainly gram-negative bacteria （ 63.89% ）. Levels of liver fibrosis and liver function index in patients with biliary obstruction complicated by biliary infection were higher than in those without biliary tract infection and in the control group （P 〈 0.05 ）. Biliary tract obstruction complicated by biliary tract infection was positively correlated with liver fibrosis （P 〈 0.05 ）. Conclusions Patients with biliary obstruction are more likely to have biliary infections. Liver damage is more severe in patients with biliary tract obstruction complicated by biliary tract infection. We should actively focus on patients with biliary obstruction complicated by biliary tract infections.

关 键 词：胆道梗阻 胆道感染 肝纤维化 肝功能 

分 类 号：R575.2[医药卫生—消化系统]