吡格列酮联合维生素E治疗非酒精性脂肪肝的临床观察  

Application of pioglitazone combined with vitamin E in the treatment of non-alcoholic fatty liver disease

作　　者：卓宇宏 陈其慧[1] 周小戈[1] 韩晖 ZHUO Yu-hong;CHEN Qi-hui;ZHOU Xiao-ge;HAN Hui(Gastroenterology Department,Zhanjiang Central People＇s Hospital,Zhanjiang 524037,China)

机构地区：[1]广东省湛江中心人民医院消化内科,广东湛江524037

出　　处：《广东医科大学学报》2018年第2期230-232,共3页Journal of Guangdong Medical University

摘　　要：目的观察吡格列酮联合维生素E在治疗非酒精性脂肪肝(NAFLD)中的应用价值。方法 105例NAFLD患者随机分为A、B、C 3组,每组35例。A组采用吡格列酮治疗,B组采用维生素E治疗,C组采用吡格列酮联合维生素E治疗。评估3组的疗效,检测3组治疗前后的肝功能指标、血脂指标和胰岛素敏感性指标。结果 C组的疗效明显好于A、B组(P<0.05),治疗后的丙氨酸氨基转移酶、天门冬氨酸基转移酶、总胆固醇和甘油三酯水平均明显低于A、B组(P<0.05)。结论采用吡格列酮联合维生素E治疗NAFLD可提高疗效,改善肝功能,降低血脂和减轻胰岛素抵抗。Objective To investigate the application of pioglitazone combined with vitamin E in the treatment of nonalcoholic fatty liver disease（NAFLD）. Methods One hundred and five patients with NAFLD were divided into Group A,Group B and Group C by random number table method, 35 cases in each group. Group A was treated with pioglitazone, Group B was treated with vitamin E and Group C was treated with pioglitazone combined with vitamin E. The curative effect of the three groups was evaluated. The liver function index, blood lipid index and insulin sensitivity index in the three groups were detected. Results The curative effect of Group C was significantly better than that of Group A and Group B（P〈0.05）. The concentration of alanine aminotransferase, aspartate aminotransferase, total cholesterol and triglyceride in Group C after treatment were significantly lower than those in Group A and Group B（P〈0.05）. Conclusion The application of pioglitazone combined with vitamin E in the treatment of NAFLD can improve the curative effect and the liver function and also can reduce the blood lipid concentration and insulin resistance.

关 键 词：非酒精性脂肪肝 吡格列酮 维生素E 

分 类 号：R575[医药卫生—消化系统]