Synthesis,Crystal Structure and Evaluations of Its Cytotoxicity,Anti-microbial and Anti-hydroxyl Radical Activities of a New Co-crystal Compound(C6H6Cl2N2O2S)·(Phen)·H2O  

作　　者：黄岚珍 王雅楠 蔡卓 秦秀英 

机构地区：[1]College of Pharmacy,Guilin Medical University [2]Center for Science Research, Guilin Medical University [3]School of Chemistry and Chemical Engineering, Guangxi University

出　　处：《Chinese Journal of Structural Chemistry》2018年第7期1078-1086,共9页结构化学（英文）

基　　金：Supported by Guangxi Natural Science Foundation(No.2016GXNSFAA380292);National Natural Science Foundation of China(No.21661011)

摘　　要：Co-crystal is a very potential kind of drug solid forms, and has a far-reaching influence on designing and preparing drugs. A new 1：1：1 co-crystal compound consisting of 4-amino-3,5-dichloro-benzenesulfonamide, 1,10-phenanthroline and water was synthesized, and its crystal structure was characterized by X-ray diffraction method. The compositions of the co-crystal are self-assembled into a three-dimensional network structure via intermolecular interactions including hydrogen bonds, π-π stacking, Cl？？？Cl interactions and van der Waals＇ forces. According to the evaluations of cytotoxicity assays, anti-microbial and anti-hydroxyl radicals, this co-crystal is a potential drug.Co-crystal is a very potential kind of drug solid forms, and has a far-reaching influence on designing and preparing drugs. A new 1：1：1 co-crystal compound consisting of 4-amino-3,5-dichloro-benzenesulfonamide, 1,10-phenanthroline and water was synthesized, and its crystal structure was characterized by X-ray diffraction method. The compositions of the co-crystal are self-assembled into a three-dimensional network structure via intermolecular interactions including hydrogen bonds, π-π stacking, Cl？？？Cl interactions and van der Waals＇ forces. According to the evaluations of cytotoxicity assays, anti-microbial and anti-hydroxyl radicals, this co-crystal is a potential drug.

关 键 词：4-amino-3 5-dichloro-benzenesulfonamide CO-CRYSTAL CYTOTOXICITY ANTI-MICROBIAL anti-hydroxyl radical 

分 类 号：O6[理学—化学]