海藻酸钠微球与碘化油在原发性肝癌治疗中的并发症比较  

Comparison of the complications of kelp micro gelation and lipiodol in the treatment of primary hepatic carcinoma

作　　者：陈威[1] 李智岗[2] 王瑞锋[1] CHEN Wei;LI Zhigang;WANG Ruifeng(Department of Interventional Radiology,The People＇s Hospital of Xingtai,Xingtai 054031,P.R.China;Department of Interventional Radiology,Fourth Hospital of Hebei Medical University,Shijiazhuang 050000,P.R.China)

机构地区：[1]河北省邢台市人民医院介入放射科,河北邢台054031 [2]河北医科大学第四医院介入放射科,河北石家庄050000

出　　处：《医学影像学杂志》2018年第8期1308-1310,共3页Journal of Medical Imaging

摘　　要：目的对比海藻酸钠微球与碘化油在原发性肝癌治疗中的并发症,探讨海藻酸钠微球应用的安全性。方法收集我院2015年3月~2017年3月行KMG的患者21例设为实验组,随机抽取同时期行TACE的患者21例设为对照组,比较两组患者发热、疼痛、恶心、呕吐等并发症和肝功能的变化。用SPSS 17. 0软件进行统计学分析,采用2检验,检验水准α=0. 05。结果实验组21例,发热20例,疼痛19例,恶心9例,呕吐5例。对照组21例,发热18例,疼痛12例,恶心3例,呕吐1例。两组患者在发热和呕吐上没有统计学差异(2=1. 105,P=0. 293,2=3. 1,P=0. 078)。但是在疼痛和恶心的差异上有统计学意义(2=6. 035,P=0. 014,2=4. 200,P=0. 040)。肝功能变化随访,实验组AST、ALT、TBIL分别为(12±6. 32) ng/ml、(23±10. 21) ng/ml、(8. 8±2. 12) ng/ml。对照组(14±3. 46) ng/ml、(20±13. 37) ng/ml、(7. 6±4. 11) ng/ml。统计学分析发现两组患者各指标变化没有统计学差异(t=1. 31,P=0. 202、t=0. 82,P=0. 613、t=1. 18,P=0. 850)。结论海藻酸钠微球较碘化油栓塞剂的并发症更明显,但是尚在安全可控制的范围内,在控制好并发症的基础上可以推广应用。Objective To compare the complications of kelp micro gelation and lipiodol in the treatment of primary hepatic carcinoma,and to explore the safety of the application of kelp micro gelation. Methods Data was collected from 21 patients under the treatment of KMG in March,2015-March 2017 as experimental group,and 21 patients chosen randomly under the treatment of TACE at the same period of time as controlled group. These two groups of patients were compared in terms of fever,pain,nausea,vomiting and other complications,and the change of liver function. Data were analyzed with SPSS 17. 0,2 test was adopted,and the test level was 0. 05. Results Of 21 cases in experimental group,20 presented with fever,19 with pain,9 with nausea and 5 with vomiting,while,of 21 cases in controlled group 18 presonted with fever,12 with pain,3 with nausea,5 with vomiting. There was no statistical difference between the two groups in fever and vomiting（2= 1. 105,P = 0. 293,2= 3. 1,P= 0. 078）. However,there was statistically significant difference between pain and nausea（2= 6. 035,P = 0. 014,2=4. 200,P = 0. 040）. In the follow-up of liver function changes,the AST,ALT and TBIL of the experimental group were（12 ±6. 32） ng/ml,（23 ± 10. 21） ng/ml and（8. 8 ± 2. 12） ng/ml respectively. While,those of controlled group were（14 ± 3. 46）ng/ml,（20 ± 13. 37） ng/ml and（7. 6 ± 4. 11） ng/ml. No significant difference between the two groups of patients（t = 1. 31,P = 0. 202,t = 0. 82,P = 0. 613,t = 1. 18,P = 0. 850） was shown in this statistical analysis. Conclusion The complication of kelp micro gelation is more serious than that of Lipiodol embolization agent,but it is still within the controllably safe range and can be popularized on the basis of controlling the complications.

关 键 词：肝癌 海藻酸钠微球 碘化油 并发症 

分 类 号：R735.7[医药卫生—肿瘤] R815[医药卫生—临床医学]