炎性肠病的脑功能磁共振研究进展  

The progress of brain functional magnetic resonance on inflammatory bowel disease

作　　者：郭会映[1] 朱建国[1] GUO Huiying;ZHU Jianguo(The Second Affiliated Hospital of Nanjing Medical University,Nanjing 211166,P.R.China)

机构地区：[1]南京医科大学第二附属医院放射科,江苏南京211166

出　　处：《医学影像学杂志》2018年第8期1380-1383,共4页Journal of Medical Imaging

基　　金：南京医科大学科技发展基金重点项目(编号:2015NJMUZD035);江苏省省级条件建设与民生科技专项资金项目(编号:BL2014097)

摘　　要：溃疡性结肠炎、克罗恩病是一类具有慢性、复发性和缓解性等临床特点的肠道疾病,临床上将这类疾病统称为炎性肠病。神经心理学研究表明炎性肠病与压力、情绪障碍、心理障碍以及认知功能的受损有关。并且,由于该类疾病具有复发性与缓解性相交替的特点,即使在缓解期,由于疾病复发的不可预知性及不确定性仍会导致患者的焦虑、抑郁,从而进一步导致疾病的复发。利用血氧水平依赖的功能磁共振(blood oxygenation level-dependent functional magnetic resonance imaging,BOLD-f MRI)技术以及基于体素的形态学测量(voxel-based morphometry,VBM)对脑神经元活动及形态结构的研究已经取得初步的研究成果。本文旨在综述炎性肠病患者形态学的改变、脑神经元活动与炎性肠病间的相互作用和该领域脑功能影像学的研究进展。Ulcerative colitis or crohn＇s disease is a kind of chronic,relapsing and relieving clinical intestinal disease. Clinically,these diseases were collectively known as inflammatory bowel disease. Neuropsychological studies have shown that inflammatory bowel diseases have relationship with stress,mood disorders,mental disorders and cognitive function. Because the disease is characterized by alternation of recurrent and remission,even in remission,the recurrence of disease is unpredictability and uncertainty,which will lead to the patient＇s anxiety and depression,and further lead to disease recurrence. Use of blood oxygen level dependent functional magnetic resonance（BOLD-f MRI） technology on brain neurons activity and measurement based on voxel morphology（VBM） of morphological structure have made preliminary research results. The purpose of this paper is to review the interaction of brain morphology,cranial neurons activity and inflammatory bowel disease,and the research progress of functional brain imaging in this field.

关 键 词：炎性肠病 脑肠轴 功能磁共振 VBM 

分 类 号：R574[医药卫生—消化系统] R445.2[医药卫生—内科学]