高危急性淋巴细胞白血病患儿维持治疗阶段营养状况与重症感染的关系研究  

Relationship between nutritional status and severe infection during maintenance treatment in children with high-risk acute lymphoblastic leukemia

作　　者：李智英[1] 张婷婷[1] 黄惠[2] 钟婷[3] 蔡敏 Li Zhiying;Zhang Tingting;Huang Hui;Zhong Ting;Cai Min(Department of Pediatrics,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]中山大学附属第一医院儿科,广州510080 [2]中山大学肿瘤防治中心儿科,广州510060 [3]中山大学孙逸仙纪念医院儿科,广州510120

出　　处：《新医学》2018年第9期648-650,共3页Journal of New Medicine

基　　金：广东省医学科学技术研究基金(A2015163)

摘　　要：目的探讨高危急性淋巴细胞白血病(ALL)患儿在维持治疗阶段的不同营养状况及其对重症感染发生率的影响。方法收集高危ALL患儿,调查其在维持治疗阶段的营养状况,并比较不同营养状况下重症感染的发生率。结果共168例高危ALL患儿纳入研究,其中营养良好、轻度营养不良及中度、重度营养不良的患儿分别占23.2%、40.5%、24.4%、11.9%,其并发重症感染的发生率分别为15.4%、14.7%、41.5%、60.0%,组间比较差异有统计学意义(P<0.001),重度营养不良组患儿的重症感染发生率高于营养良好组及轻度营养不良组患儿(P均<0.001),中度营养不良组的重症感染发生率高于轻度营养不良组(P<0.008)。结论高危ALL患儿在维持治疗阶段营养状况不容乐观,重症感染发生率与不同营养状况有关,营养状况越差,发生重症感染的风险越高。Objective To evaluate the effect of different nutritional status upon the incidence of se- vere ilffeetion during the maintenance therapy in children diagnosed with high-risk acute lymphoblastie leukenfia （ALL）. Methods The nutritional status of the high-risk ALL children was assessed. The incidence of severe ilffeetions under different nutritional conditions was statistically compared. Results A total of 168 high-risk ALL children were enrolled in this study. Among them, the percentage of patients with good nutrition, nfild, moderate and severe malnutrition was 23.2% , 40. 5% , 24.4% and 11.9% , respectively. The incidence of severe concurrent ilffeetions was 15.4% , 14. 7% , 41.5% and 60. 0% , respectively, which significantly dif- fered among different groups （ P 〈 0. 001 ）. The incidence of severe ilffeetion in the severe malnutrition group was significantly higher than that in the good nutrition and nfild malnutrition groups （ both P 〈 0. 001 ）. The incidence of severe ilffeetion in the moderate malnutrition group was considerably higher than that in the nfild mal- nutrition group （P 〈 0. 008 ）. Conclusions The nutritional status of high-risk ALL children during the maintenanee treatment are not optinfistie. The incidence of severe ilffeetion is associated with different nutritional status. The worse the nutritional status is, the higher risk of severe infection is.

关 键 词：营养不良 重症感染 急性淋巴细胞白血病 儿童 

分 类 号：R733.7[医药卫生—肿瘤]