肝动脉灌注化疗栓塞及微波消融对肝癌患者细胞免疫及体液免疫临床意义分析  

The Effects of Transcather Hepatic Arterial Chemoembolization Combined with Percutaneous Microwave Coagulation Therapy on Cellular Immunity and Humoral Immunity in Patients with Liver Cancer

作　　者：曹庆柱[1] CAO Qingzhu(The 210th Hospital of PLA,Dalian,116021)

机构地区：[1]中国人民解放军第210医院,116021

出　　处：《实用癌症杂志》2018年第9期1407-1410,1414,共5页The Practical Journal of Cancer

摘　　要：目的探究肝动脉灌注化疗栓塞联合微波消融对原发性肝癌患者的疗效及其对细胞免疫及体液免疫功能的影响。方法将122例原发性肝癌患者按随机数字表法分为对照组和观察组,每组61例。对照组给予单一肝动脉灌注化疗栓塞法,观察组给予肝动脉灌注化疗栓塞法联合微波消融治疗,观察两组患者临床治疗效果、不良反应发生率,体液免疫指标Ig A、Ig M、Ig G、补体C3、补体C4及细胞免疫指标CD4+、CD8+、CD4+/CD8+、NK细胞水平变化。结果对照组有40(65.57%)例患者治疗有效,观察组有56(91.80%)例患者治疗有效,观察组的治疗有效率明显高于对照组,两组比较具有统计学差异(P<0.05)。与对照组治疗后相比,观察组治疗后Ig M、Ig G水平明显升高,补体C3水平明显降低,具有统计学差异(P<0.05)。与对照组治疗后比较,观察组CD4+、CD4+/CD8+明显升高、CD8+明显降低、NK细胞增多,两组治疗后比较具有统计学差异(P<0.05)。两组患者不良反应发生率不具有统计学差异(P>0.05)。结论TACE联合PMCT治疗中晚期肝癌可针对性的杀死肿瘤细胞,提高机体免疫功能,获得良好的临床治疗效果。Objective To explore the clinical effects of transcather hepatic arterial chemoembolization combined with percutaneous microwave coagulation therapy for patients with liver cancer and the effects on cellular immunity and humoral immunity. Methods 122 cases of primary liver cancer patients were divided into the control group and the observational group according to random number table method,61 cases in each group. The control group was given transcather hepatic arterial chemoembolization（ TACE） while the observational group was given TACE combined with percutaneous microwave coagulation（ PMCT） therapy. The clinical therapeutic effect,the incidence of adverse reactions,humoral immune index IgA,IgM and IgG,complement C3,complement C4 and cellular immune index CD4^＋,CD8^＋,CD4^＋/CD8^＋,NK cell were observed of the 2 groups. Results There were 40 cases（ 65. 57%） with effective treatment in the control group,there were 56 cases（ 91. 80%） with effective treatment in the observation group,the rate of effective treatment of the observational group was obviously higher than that of the control group,there was statistically difference（ P〈0. 05）. The IgM and IgG were increased,the complement C3 was decreased compared with the control group after treatment,there were statistically difference（ P〈0. 05）. The CD4^＋,CD4^＋/CD8^＋,NK cells were increased,the CD8^＋was decreased compared with the control group after treatment,there were statistically difference（ P〈0. 05）.There was no statistically difference of the 2 groups in the incidence of adverse reactions（ P〉0. 05）. Conclusion The treatment of TACE combined with PMCT for locally advanced hepatocellular carcinoma can be targeted to kill cancer cells,improve the body＇s immune function,gain good clinical therapeutic effects.

关 键 词：肝动脉灌注化疗栓塞 微波消融 肝癌 细胞免疫 体液免疫 

分 类 号：R735.7[医药卫生—肿瘤]