肺癌患者营养状况与放疗不良反应的相关性研究  

Relationship between Nutritional Status and Radiotoxicity in Patients with Lung Cancer

作　　者：陈文政 张春华[1] 王晓松[1] 徐宝兰[1] 洪金花[1] 王杏英[1] 罗淑兰[1] 万显秀[1] 石冬梅[1] 刘桂凤[1] CHEN Wenzheng;ZHANG Chunhua;FANG Xiaosong(Jiangxi Cancer Hospital,Nanchang,33002)

机构地区：[1]江西省肿瘤医院,330029

出　　处：《实用癌症杂志》2018年第9期1439-1441,1460,共4页The Practical Journal of Cancer

摘　　要：目的探讨肺癌患者放疗期间营养状况与放疗不良反应的相关性。方法调查174例肺癌患者放疗前的营养状况,并在放疗前和放疗2周末、4周末、放疗结束时评价放疗不良反应。采用广义加性模型分析肺癌患者营养综合状况和放疗不良反应的关系。结果根据营养综合指标判断,入院时44例(25.2%)患者营养状况良好,90例(51.7%)存在轻度营养不良,40例(23.1%)存在严重营养不良。患者营养状况与放射性皮炎(t=-4.58,P<0.001),放射性食管炎(t=-5.62,P<0.001),疲劳(t=-3.98,P<0.001),放射性肺炎(t=-2.57,P<0.001)存在线性关系。结论肺癌患者的营养状况与放疗不良反应之间存在着一定的相关性,营养不良的患者在放疗前应给予营养支持。Objective To investigate the relationship between preradiation nutritional status and radiotoxicity in patients with lung cancer. Methods Nutritional status before radiotherapy and radiotoxicity of 174 cases with lung cancer were prospectively surveyed. Radiotoxicities before radiation,2 weeks and 4 weeks after beginning of radiation,and the end of radiation were assessed respectively. Relationships between nutritional status and radiotoxicities were analyzed by generalized additive models.Results According to comprehensive evaluation of nutritional status,of all the cases,normal,mild and severe were 40（ 23. 1%）,90（ 51. 7%） and 40（ 23. 1%） respectively. Linear relationships were found between nutritional status and radiation dermatitis（ t=-4. 58,P〈 0. 001）,radiation esophagitis（ t =-5. 62,P〈 0. 001）,fatigue（ t =-3. 98,P 〈0. 001）,radiation pneumonitis（ t=-2. 57,P 0. 001）. Conclusion Nutritional status is correlated with acute radiotoxicities in lung cancer patients. Malnourished patients should be offered nutritional support before radiotherapy.

关 键 词：肺癌 营养状况 放射治疗 放疗不良反应 

分 类 号：R734.2[医药卫生—肿瘤]