周剂量奈达铂同步后程加速超分割放疗联合体外高频热疗治疗局部晚期食管癌的临床研究  

Clinical Study of Weekly Dose of Nedaplatin in Combination with High-frequency Hyperthermia in the Treatment of Locally Advanced Esophageal Cancer

作　　者：庞洁[1] 陈岚[1] 陈凤[1] PANG Jie;CHEN Lan;CHEN Feng(Panzhihua Central Hospital,Panzhihua,617000)

机构地区：[1]四川省攀枝花市中心医院,617000

出　　处：《实用癌症杂志》2018年第9期1484-1488,共5页The Practical Journal of Cancer

摘　　要：目的探讨周剂量奈达铂同步后程加速超分割放疗联合体外高频热疗治疗局部晚期食管癌的临床疗效。方法收集75例局部晚期食管癌患者随机分为三组,放化疗标准组患者给予放化疗标准治疗,放化疗实验组患者给予放化疗实验组治疗,放化热疗实验组患者给予放化热疗实验治疗,比较3组患者近期治疗效果、不良反应、生存质量与生存率。结果放化热疗实验组临床主症、瘤体变化、进食梗阻、胸骨后疼痛与吐粘液症状显效率显著性高于其他两组;临床主症、瘤体变化与进食梗阻有效率显著性高于放化疗标准组;瘤体变化有效率显著性高于放化疗实验组;治疗后1个月躯体功能、心理功能、社会功能、共性症状与副作用、特异模块、共性模块与模块总分组间比较,均显著性高于其他两组;治疗后6个月生存率显著性高于放化疗标准组,存在显著性差异(P<0.01);胸骨后疼痛有效率明显高于放化疗标准组;进食梗阻与胸骨后疼痛有效率明显高于放化疗实验组;治疗后1年生存率明显高于放化疗标准组,存在明显差异(P<0.05)。结论周剂量奈达铂同步后程加速超分割放疗联合体外高频热疗治疗局部晚期食管癌的临床疗效显著,具有借鉴意义。Objective To explore the clinical effect of weekly dose of nedaplatin in combination with high frequency hyperthermia in the treatment of locally advanced esophageal cancer. Methods 75 patients with locally advanced esophageal cancer were randomly divided into 3 groups. The standard radiotherapy and chemotherapy group was treated with radiotherapy and chemotherapy. The patients in experimental radiotherapy and chemotherapy group was given experimental radiotherapy and chemotherapy treatment. The hyperthermia radiotherapy and chemotherapy group was given hyperthermia radiotherapy and thermotherapy The experimental treatment was performed to compare. T. he short-term treatment effects,adverse reactions,quality of life and survival rate in the 3 groups were compared. Results The main clinical symptoms,tumor changes,eating obstruction,posterior sternal pain and spit mucus were significantly higher in the hyperthermia group than in the other 2 groups. The clinical main symptoms,tumor changes and eating obstruction were significant higher（ P〈0. 05）. There was significant difference between the 2 groups in terms of somatic function,psychological function,social function,common symptoms and side effects,specific module,common module and general subgroup（ P〈 0. 01）. The effective rate of posterior sternal pain was significantly higher than that of radiotherapy and chemotherapy standard group. The difference was statistically significant（ P 〈0. 01）. The rate of survival was significantly higher than that of radiotherapy and chemotherapy group（ P〈0. 05）. The 1-year survival rate was significantly higher than that of radiotherapy and chemotherapy group（ P〈0. 05）. Conclusion Weekly dose of nedaplatin combined with accelerated late hyperfractionation radiotherapy combined with in vitro high frequency hyperthermia treatment of locally advanced esophageal cancer has a significant clinical effect,and has reference significance.

关 键 词：奈达铂 三维适形放疗 加速超分割放疗 体外高频热疗 食管癌 

分 类 号：R735.1[医药卫生—肿瘤]