甲状腺癌术后促甲状腺激素抑制治疗与甲状腺激素替代治疗的疗效对比  

Comparison of Thyroid Hormone Suppression Therapy and Thyroid Hormone Replacement Therapy after Thyroidectomy

作　　者：韩淼[1] 周长明[1] 赵康[1] HAN Miao;ZHOU Changming;ZHAO Kang(Yan＇an University Affiliated Hospital,Yan＇ an,716000)

机构地区：[1]延安大学附属医院,716000

出　　处：《实用癌症杂志》2018年第9期1550-1552,共3页The Practical Journal of Cancer

摘　　要：目的比较甲状腺癌术后促甲状腺激素(TSH)抑制治疗与甲状腺激素替代治疗的临床效果。方法采用抽签法将60例分化型甲状腺癌分为研究组与对照组,各30例,分别采用TSH抑制治疗和甲状腺激素替代治疗,比较2组术后3年、5年的复发、转移情况及不良反应。结果 2组术后3年的复发率、颈部淋巴结转移率及远处转移率差异无统计学意义(P>0.05),但术后5年研究组明显低于对照组(P<0.05)。2组不良反应发生率差异无统计学意义(P>0.05)。结论 TSH抑制治疗比甲状腺激素替代治疗能更有效地减少分化型甲状腺癌术后的复发、转移危险,但应制定个体、动态的TSH抑制治疗方案,以达到临床获益与安全性的平衡。Objective To compare the clinical benefits of thyroid stimulating hormone（ TSH） suppression therapy and thyroid hormone replacement therapy after thyroid cancer surgery. Methods 60 cases of differentiated thyroid carcinoma were divided into the study group and the control group according to the lottery method,30 cases in each group,and were treated with TSH suppression therapy and thyroid hormone replacement therapy respectively. The recurrence,metastasis after 3 years and 5 years and adverse reactions were compared between the 2 groups. Results The recurrence rate,neck lymph node metastasis rate and distant metastasis rate of the 2 groups after 3 years were not statistically significant（ P〉0. 05）,after 5 years,the study group was significantly lower than the control group（ P〈0. 05）. The incidence of adverse reactions in the 2 groups was not statistically significant（ P〉0. 05）. Conclusion TSH suppression therapy is more effective than thyroid hormone replacement therapy in reducing the risk of recurrence and metastasis after differentiated thyroid cancer surgery,however,an individual and dynamic TSH suppression regimen should be developed to achieve a balance between clinical benefit and safety.

关 键 词：甲状腺癌 促甲状腺激素抑制治疗 甲状腺激素替代治疗 

分 类 号：R736.1[医药卫生—肿瘤]