AQP1和AQP4在中枢神经系统疾病中研究进展  

Research progress of AQP1 and AQP4 in central nervous system

作　　者：杜琼[1] 周敬华[1] DU Qiong;ZHOU Jing-hua(The First College of Clinical Medical Science,China Three Gorges University/Department of Neurology,Yichang Central People＇s Hospital,Yechang 443003,Hubei,CHINA)

机构地区：[1]三峡大学第一临床医学院宜昌市中心人民医院神经内科,湖北宜昌443003

出　　处：《海南医学》2018年第16期2315-2318,共4页Hainan Medical Journal

摘　　要：水通道蛋白(AQPs)是一跨膜蛋白家族,由6次跨膜的单肽链组成,主要调节体内水的转运。在中枢神经系统已经发现9种水通道蛋白,即AQP1、AQP3、AQP4、AQP5、AQP6、AQP7、AQP8、AQP9、AQP11。其中AQP1和AQP4是中枢神经系统中两种最主要的水通道蛋白。近年来,AQP1和AQP4日益受到重视,目前其被认为是多种疾病的特异标记物,其含量的变化可影响某些中枢神经系统疾病的发生发展。通过深入研究AQP1和AQP4在中枢神经系统疾病中的变化,有助于阐明疾病的发病机制,为中枢神经系统疾病的诊断和治疗提供新的思路和方法。Aquaporins（AQPs）, a member of transmembrane protein family, are composed of six membrane-spanning monopeptide chains, which mainly mediate water flux in the body. Nine AQPs have been identified in the central nervous system： AQP1, AQP3, AQP4, AQP5, AQP6, AQP7, AQP8, AQP9, AQP11. AQP1 and AQP4 are two of the most important water-channel proteins in the central nervous system. Recently, AQP1 and AQP4 are increasingly valued and now considered a specific marker for a variety of diseases. Changes in their content can affect the development of certain CNS diseases. Further study on the changes of AQP1 and AQP4 in CNS diseases will help to clarify the pathogenesis of CNS diseases and provide new ideas and methods for diagnosis and treatment of CNS diseases.

关 键 词：水通道蛋白1 水通道蛋白4 脑水肿 胶质细胞瘤 阿尔茨海默病 视神经脊髓炎 

分 类 号：R741.02[医药卫生—神经病学与精神病学]