乙型肝炎表面抗原携带率的评估:2016年来自医院横断面调查  

Evaluation of HBsAg carrier rate:a cross-sectional study from hospital data

作　　者：李威[1] 吴亚男 丁岗强[1] 康谊[1] 尚佳[1] LI Wei;WU Ya-nan;DING Gang-qiang;KANG Yi;SHANG Jia(Department of Infectious Diseases,People＇s Hospital of Henan Province,Zhengzhou,Henan 450003,China)

机构地区：[1]河南省人民医院感染科,河南郑州450003

出　　处：《中国病毒病杂志》2018年第4期309-312,共4页Chinese Journal of Viral Diseases

基　　金：河南省自然科学基金资助项目(162300410294)

摘　　要：目的探讨医院住院患者乙型肝炎表面抗原(HBsAg)携带率的血清流行病学意义。方法收集2016年1~12月河南省人民医院住院患者HBsAg检测结果,剔除易导致研究偏倚的肝病相关科室患者,评估HBsAg携带率。结果共收集2016年1~12月筛查HBsAg的住院患者102 603例。平均年龄为(48.4±20.8)岁,男性52 088例,女性50 515例;手术科室49 302例,非手术科室53 301例。与非手术科室比较,手术科室患者的年龄、性别、城乡及地域分布较为均衡。2016年所有年龄段住院患者总体HBsAg阳性率为4.34%(4 455/102 603)。手术科室患者HBsAg阳性率为4.40%(2 170/49 302);非手术科室患者HBsAg阳性率为4.29%(2 285/53 301)。1~59岁手术科室住院患者HBsAg携带率为4.48%。其中,1~14岁(2002年乙肝疫苗计划免疫后出生)手术科室住院患者HBsAg携带率为0.31%,显著低于其他年龄段。结论医院手术科室(肝病相关科室除外)住院患者在一定程度上反映了人群HBV的感染率。14岁以下人群HBsAg携带率较低。Objective To explore the feasibility of evaluating HBsAg carrier rate based on the big data available in hospitals,and to understand the current status of HBV infection. Methods A total of 102 603 inpatients whose demographic data was obtained from the information system of the hospital from January to December2016;inpatients at liver-related departments were excluded to reduce the bias.The patients were divided into two groups based on their departments：surgery and non-surgery departments.An applicable model was established to assess the HBsAg positive rate. Results All 102 603 patients were enrolled.The mean age was（48.4±20.8）years old.Comparing to non-surgery departments,the number of patients in surgery departments showed balanced distributions in age,sex and origin.The overall positive rate of HBsAg was 4.34%（4 455/102 603）;4.40%（2 170/49 302）and 4.29%（2 285/53 301）among surgery and non-surgery departments,respectively.The overall HBsAg positive rate of 1-59 age groups was 4.48% while only 0.31% among patients equal to or under 14 years old. Conclusions Evaluation of the HBsAg carrier rate in the general population might be feasible using the study model of hospital-based big data.The HBsAg carrier rate was significantly lower among people under 14 years old in Henan province of China.

关 键 词：乙型肝炎表面抗原 携带率 住院患者 横断面调查 流行病学 

分 类 号：R512.62[医药卫生—内科学]