糖尿病患者超声乳化术后眼表及角膜内皮细胞观察  

Obesrvation on the ocular surface and corneal endothelial cells in diabetic patients after phacoemulsification

作　　者：姬翔[1] 沈玲[1] Ji Xiang;Shen Ling(Deparment of Ophthalmology,Jiaozuo People＇s Hospital,Jiaozuo,Henan 454100,China)

机构地区：[1]焦作市人民医院眼科,河南454100

出　　处：《中华眼外伤职业眼病杂志》2018年第8期601-605,共5页Chinese Journal of Ocular Trauma and Occupational Eye Disease

摘　　要：目的 观察糖尿病患者超声乳化术术后眼表及角膜内皮细胞的情况.方法 84例（84眼）白内障行超声乳化术,其中糖尿病者42例（42眼）为糖尿病组;单纯白内障（非糖尿病者）42例（42眼）为单纯组.两组患者由同一医师进行透明角膜切口手术,术前均无干眼症状,糖尿病组血糖控制正常,无眼底改变.分别于术前及术后3d、7d、1个月比较两组患者干眼症状评分、角膜内皮细胞密度.结果 两组患者术前干眼症状评分、角膜内皮细胞密度、泪液分泌试验（SIt）、角膜荧光染色（FL）评分以及泪膜破裂时间（BUT）差异均无统计学意义（P=0.9993,0.5561,0.8237,0.1305,0.8357）.糖尿病组术后3d干眼症状评分与单纯组差异无统计学意义（P =0.1986）,而术后7d和1个月均显著高于单纯组（P 〈0.001）.糖尿病组术后3d、7d,1个月角膜内皮细胞密度均显著低于单纯组（P 〈0.001）,SIt及FL评分均显著高于单纯组（P =0.0001）.糖尿病组术后3 d BUT与单纯组差异无统计学意义（P =0.6397）,而术后7d、1个月均显著低于单纯组,差异有统计学意义（P〈0.05）.结论 对糖尿病患者的超声乳化术可显著影响其干眼症状、SIt以及BUT等指标,可能与患者对损伤的修复能力降低有关.Objective To observe the ocular surface and corneal endothelial cells in diabetic patients after phacoemulsification.Methods Eighty-four eyes of 84 cases of cataract received phacoemulsification.Among them 42 eyes of 42 cases with diabetic mellitus were diabetic group,42 eyes of 42 cases without diabetes were the pure group.No dry eye symptom before surgery occurred.All patients underwent phacoemulsification with corneal incision by the same doctor.No change of ocular fundus for diabetic patients occurred,and preoperative glycemic control was normal.Dry eye symptoms,corneal endothelial cell density,Schirmer Ⅰ test （SIt）,corneal fluorescein staining （FL） score and lacrimal film breakup time （BUT） were compared between the two groups at preoperatively and postoperatively 3,7 days and 1month.Results The difference of dry eye symptoms score,corneal endothelial cell density,SIt,FL score and BUT before operation were not statistically significant between 2 groups （P =0.9993,0.5561,0.8237,0.1305,0.8357）.The difference of dry eye symptoms at 3 days after operation was not significant between 2 groups （P =0.1986）.The dry eye symptoms score of diabetic group were higher than those in the pure group at 7 days and 1 month after operation （P 〈 0.001）.The corneal endothelial cell density after operation in diabetic group was lower than that in pure group.The difference was statistically significant （P 〈0.001）.The SIt and FL scores in diabetic group were significantly higher than those in pure group,the difference was statistically significant （P =0.0001）.The difference of BUT was not significant between 2 groups at 3 days after operation （P =0.6397）,but the BUT of diabetic group at 7 days and 1 month after operation was significantly lower than that of pure group,the difference was statistically significant （P 〈 0.001）.Conclusion There is effect of phacoemulsification on dry eye symptoms,SIt and BUT for patients with diabetes mellitus,and which may be related to the impaired repa

关 键 词：角膜内皮细胞密度 非糖尿病者 超声乳化术 术后 患者 细胞观察 眼表 干眼症状 

分 类 号：R779.66[医药卫生—眼科] R587.2[医药卫生—临床医学]