等剂量西甲硅油乳剂口服或直接肠内注入对肠镜视野清晰度的影响  

Effect of oral administration versus direct enteral injection of same dose of simethicone emulsion on mucosal visualization at colonoscopy

作　　者：李阳[1] 屈亚威[1] 高健翎 高智 刘海峰[1] LI Yang;QU Yawei;GAO Jianling;GAO Zhi;LIU Haifeng(Department of Gastroenterology,General Hospital of Chinese People＇s Armed Police Force,Beijing 100039,China)

机构地区：[1]武警总医院消化内科,北京100039

出　　处：《解放军医学院学报》2018年第8期682-684,共3页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金面上项目(81471700)~~

摘　　要：目的探讨等剂量西甲硅油乳剂口服或直接肠内注入对肠镜视野清晰度的影响。方法选择2016年5月-2017年5月在我院内镜中心接受肠镜检查的100例患者作为研究对象,随机分成2组,每组50例。在常规口服导泻药进行肠道准备的基础上,对照组在肠镜检查前4 h口服西甲硅油乳剂30 ml,实验组将西甲硅油乳剂30 ml溶于500 ml 0.9%氯化钠注射液,在进镜过程中直接注入肠道,比较两组患者的肠道清洁度、肠腔内气泡量以及息肉检出率。结果实验组和对照组清晰视野所占的比例分别为84%和64%,实验组祛泡效果优于对照组(P=0.023),两组患者的肠道清洁度(72%vs 76%)和息肉检出率(46%vs 32%)无统计学差异(P均>0.05)。结论西甲硅油乳剂稀释后直接肠内注入的祛泡效果优于等剂量口服给药,能提供更为清晰的检查视野,值得临床推广和应用。Objective To explore the effect of oral administration versus direct enteral injection of same dose of simethicone emulsion on mucosal visualization at colonoscopy. Methods One hundred patients who underwent colonoscopy in our hospital from May 2016 to May 2017 were enrolled in the study, and they were randomly divided into two groups with 50 cases in each group. Patients in the control group received oral administration of 30 mL of simethicone emulsion at 4 hours before examination, and in the experimental group, 30 mL of simethicone emulsion was dissolved in 500 mL of normal saline and injected into the intestine directly. The bowel cleanliness, mucosal visibility score and the detection rate of polyp were compared between two groups. Results Overall cleansing（excellent or good） quality was significantly higher in the observation group compared to control group（84% vs 64%,P =0.023）. The effect of eliminating foam and bubbles in the observation group was better than that in the control group. There was no significant difference in bowel cleanliness（72% vs 76%） and detection rate of polyp in the intestine（46% vs 32%） between the two groups（P 0.05, respectively）. Conclusion Simethicone emulsion diluting directly into the intestine can provide a clearer inspection field compared to oral administration of the same dose, which is worthy of clinical application.

关 键 词：西甲硅油乳剂 肠镜 视野清晰度 

分 类 号：R574.62[医药卫生—消化系统]