珊瑚羟基磷灰石圆柱体骨传导能力的初步动物研究  

A preliminary animal study on osteoconduction capacity of coralline hydroxyapatite cylinders

作　　者：姚钟雄 徐淑兰 邵军 YAO Zhongxiong;XU Shulan;SHAO Jun(Department of Stomatology,Guangzhou Hospital of Integrated Traditional and West Medicine,Guangzhou 510800,Guangdong Province,China)

机构地区：[1]广州市中西医结合医院口腔科,广东广州510800 [2]南方医科大学口腔医院(广东省口腔医院)

出　　处：《中国口腔种植学杂志》2018年第2期57-60,80,共5页Chinese Journal of Oral Implantology

基　　金：2016年花都区医疗卫生科研项目(16-HDWS-029)

摘　　要：目的:通过将可降解珊瑚羟基磷灰石圆柱体植入大白兔股骨远中极限骨缺损中,探讨珊瑚羟基磷灰石圆柱体新骨的形成情况,为种植体植入的时机提供参考。方法:将30只新西兰大白兔分为实验组24只和对照组6只。实验组,在兔子股骨远中干骺端植入48块珊瑚羟基磷灰石,在4周、8周、12周时分别处死8只,行大体标本观察和组织学分析;对照组,饲养至12周时全部处死,行相应分析。结果:实验组24只大白兔均愈合良好,4周时仅植入物边缘有少量新骨形成,8周时植入物中心有明显新生骨长入,12周时植入物边缘与中心新骨形成均增加。实验组新生骨面积百分比,4周与8周之间差异具有统计学意义,8周与12周时无明显差别。对照组缺损中心仅有少量炎症细胞和成纤维细胞长入,无骨组织形成。结论:可降解珊瑚羟基磷灰石圆柱体植入兔子股骨远中极限骨缺损中后愈合良好,8周时骨块中心有新骨显著形成,此时,适合种植体的植入。Objective： The biodegradable coralline hydroxyapatite cylinder was implanted into the bone defect of the distal femur of rabbits, and the formation of new bone of coralline hydroxyapatite cylinder was discussed, so as to provide references for the timing of implant placement. Methods： 30 white New Zealand rabbits were randomly divided into 24 rabbits in the test group and 6 in the control group. In the experimental group, 48 coralline hydroxyapatite were implanted in the distal femur of the rabbit,and 8 rabbits were sacrificed at 4, 8 and 12 weeks, respectively. Gross specimens were observed and histologically analyzed. In the control group, all the animals were killed at 12 weeks, and the corresponding analysis was performed. Results： The 24 rabbits in the test group healed well. At the 4 th week, there was only a few new bone formation at the edge of the implant. At the 8 th week, there was obvious new bone ingrowth in the implant center. At the 12 th week, both the edge of the implant and the new bone in the center increased. The percentage of new bone area in the test group was statistically significant between the 4 th week and the 8 week, and there was no significant difference between the8 week and the 12 week. In the control group, only a small amount of inflammatory cells and fibroblasts grew into the defect center, and no bone tissue was formed. Conclusion： The biodegradable coralline hydroxyapatite cylinder healed well after implantation into the bone defect of rabbit femur, and at 8 weeks, new bone was formed in the center of the bone, which is suitable for implant placement.

关 键 词：珊瑚羟基磷灰石圆柱体 极限骨缺损 新骨面积百分比 骨传导性 

分 类 号：R783.1[医药卫生—口腔医学]