罂粟碱联合丹参川芎嗪治疗缺血性肠炎的疗效分析  

Analysis of efficacy of Papaverine combined with Salvia Miltiorrhiza and Ligustrazine Hydrochloride in the treatment of ischemic enteritis

作　　者：尹小菲 康文全[1] YIN Xiao-fei;KANG Wen-quan(Department of Gastroenterology,Nanshan Hospital Affiliated to Guangdong Medical College,Shenzhen 518052,China)

机构地区：[1]广东医学院附属南山医院消化内科,518052

出　　处：《中国实用医药》2018年第23期99-100,共2页China Practical Medicine

基　　金：深圳市卫生计生系统科研项目(项目编号:201403132)

摘　　要：目的探讨罂粟碱联合丹参川芎嗪在缺血性肠炎治疗中的临床疗效。方法 105例缺血性肠炎患者,随机分为治疗组(55例)和对照组(50例)。两组患者均给予常规对症支持治疗,对照组患者给予丹参川芎嗪治疗,治疗组在对照组基础上加用罂粟碱治疗。比较两组患者的临床疗效,观察两组患者的不良反应发生情况。结果治疗组腹痛消失时间和大便潜血转阴时间分别为(3.46±1.21)、(3.87±1.34)d,均短于对照组的(4.31±1.67)、(4.76±1.48)d,差异均具有统计学意义(P<0.05)。治疗组患者治疗总有效率94.55%显著高于对照组的82.00%,差异具有统计学意义(P<0.05)。两组治疗过程中均未出现与用药相关的严重不良反应,顺利完成疗程。结论罂粟碱联合丹参川芎嗪治疗缺血性肠炎较单用丹参川芎嗪疗效显著,并且安全性好,值得推广应用。Objective To explore the clinical efficacy of Papaverine combined with Salvia Miltiorrhiza and Ligustrazine Hydrochloride in the treatment of ischemic enteritis. Methods A total of 105 patients with ischemic colitis were randomly divided into the treatment group for 55 cases and the control group for 50 cases. All patients were given conventional symptomatic support therapy, the control group was treated with injection of Salvia Miltiorrhiza and Ligustrazine Hydrochloride, the treatment group was treated with Papaverine on the basis of the control group. The clinical effects of the two groups were compared, and the occurrence of adverse reactions was observed. Results The abdominal pain disappearance time and stool occult blood turn negative time of the treatment group were（3.46±1.21）d and（3.87±1.34）d respectively, which were significantly shorter than（4.31±1.67）d and（4.76±1.48）d of the control group, the differences were statistically significant（P〈0.05）. The total effective rate of the treatment group was 94.55%, which was significantly higher than 82.00% of the control group, the difference was statistically significant（P〈0.05）. No serious adverse reactions related to medication occurred in the two groups during treatment, and the course of treatment was successfully completed. Conclusion The curative effect of Papaverine combined with Salvia Miltiorrhiza and Ligustrazine Hydrochloride in the treatment of ischemic enteritis is more significant than Salvia miltiorrhiza and Ligustrazine Hydrochloride alone, it also has high security and worthy of popularization and application.

关 键 词：缺血性肠炎 罂粟碱 丹参川芎嗪 

分 类 号：R574[医药卫生—消化系统]