齐拉西酮与奥氮平对首发精神分裂症患者糖脂代谢、认知功能的影响及可能作用机制分析  

The Effects of ziprasidone and olanzapine on glucolipid metabolism and cognitive function of patients with first-episode schizophrenia and analysis of the possible mechanism of action

作　　者：衡荣[1] 罗锐 冯杰[1] 冷珂 HENG Rong;LUO Rui;FENG Jie(The Third People＇ s Hospital of Panzhihua City in Sichuan Province,Panzhihua 617061,China)

机构地区：[1]攀枝花市第三人民医院,攀枝花617061

出　　处：《国际精神病学杂志》2018年第4期594-596,603,共4页Journal Of International Psychiatry

摘　　要：目的比较齐拉西酮与奥氮平对首发精神分裂平患者糖脂代谢及认知功能的影响,分析其可能作用机制。方法选择2015年7至2016年6月期间收治的首发精神分裂症患者116例为研究对象,根据病历单双号分为齐拉西酮组与奥氮平组,各58例,齐拉西酮组给予齐拉西酮口服治疗,奥氮平组给予奥氮平口服治疗,4个月后,比较两组患者的糖脂代谢、认知功能、不良反应。结果齐拉西酮组空腹血糖(FBG)、低密度脂蛋白(LDL-C)、胆固醇(TC)、甘油三酯(TG)水平均明显低于奥氮平组(P<0.05);阳性和阴性症状量表(PANSS)评分明显低于奥氮平组,韦氏成人智力量表(WAIS-RC)数字符号评分明显高于奥氮平组(P<0.05);不良反应发生率27.59%明显低于奥氮平组51.72%(P<0.05)。结论齐拉西酮与奥氮平相较,能更有助于改善首发精神分裂症患者临床阳性与阴性症状,减少糖脂代谢及不良反应,改善认知功能。Objective To compare the effects of ziprasidone and olanzapine on glucolipid metabolism and cognitive function of patients with first-episode schizophrenia,and to analyze the possible mechanism of action. MethodsA total of 116 cases of patients with first-episode schizophrenia admitted to hospital from July 2015 to June 2016 were selected as the research objects and randomly divided into Ziprasidone group and Olanzapine group according to the odd or even number of the medical records,with 58 cases in each group. Patients in Ziprasidone group were given oral medication of Ziprasidone,and those in Olanzapine group were given oral medication of Olanzapine. After 4 months,the glucolipid metabolism,cognitive function and adverse reactions of the two groups were compared. Results The levels of fasting blood-glucose（FBG）,low-density lipoprotein cholesterol（LDL-C）,T-cholesterol（TC）and triglyceride（TG）in Ziprasidone group were significantly lower than those in Olanzapine group（P〈0.05）;the positive and negative syndrome scale（PANSS）score was significantly lower than that in Olanzapine group,the Wechsler adult intelligence scale-revised（WAIS-RC）digital symbol score was significantly higher than that in Olanzapine group（P〈0.05）;the incidence rate of adverse reactions was 27.59% and significantly lower than 51.72% in Olanzapine group（P〈0.05）. Conclusion Compared with the treatment of olanzapine,ziprasidone can be more helpful to improve the clinical positive and negative symptoms of patients with first-episode schizophrenia,reduce glucolipid metabolism and adverse reactions and improve cognitive function.

关 键 词：首发精神分裂症 齐拉西酮 奥氮平 糖脂代谢 认知功能 

分 类 号：R749.053[医药卫生—神经病学与精神病学]