无抽搐电休克对儿童精神分裂患者的疗效及其对P300和眼动的影响  

The clinical efficacy of modified electroconvulsive therapy in children with schizophrenia and its effect on cognitive function,action potential and eye movement

作　　者：李斌[1] 戚艳杰[1] 张之霞[1] 陈云 郑毅[1] LI Bin;QI Yanjie;ZHANG Zhixia(Beijing Anding Hospital,Capital Medical University,Beijing 100088,China)

机构地区：[1]首都医科大学附属北京安定医院,北京100088

出　　处：《国际精神病学杂志》2018年第4期632-634,共3页Journal Of International Psychiatry

摘　　要：目的探讨无抽搐电休克在儿童精神分裂症患者中的临床效果及对认知功能的影响。方法取儿童精神分裂症患者90例,随机数字法分为对照组(n=45)和观察组(n=45)。对照组采用利培酮治疗,观察组采用无抽搐电休克治疗,比较2组临床疗效及对认知功能的影响。结果观察组效率为97.78%与对照组84.44%比较差异有统计学意义(P<0.05);观察组治疗后1个月、2个月及3个月PANSS量表评分,均低于对照组(P<0.05);观察组治疗后电位P300的潜伏期和波幅,高于对照组(P<0.05);观察组治疗后眼动测定水平,均高于对照组(P<0.05)。结论儿童精神分裂症患者采用无抽搐电休克治疗效果理想,值得推广应用。Objective To investigate the clinical effect of modified electroconvulsive therapy（ECT）in children with schizophrenia and its influence on cognitive function. Methods A total of 90 children with schizophrenia were randomly divided into control group（n=45）and observation group（n=45）. The control group was treated with risperidone,the observation group was treated with modified electroconvulsive therapy,and the clinical efficacy and cognitive function of the 2 groups were compared. Results The observation group efficiency was 97.78% and 84.44% in the control group the difference was statistically significant（P〈0.05）;the observation group after treatment for 1 months,2 months and 3 months PANSS score were lower than the control group（P〈0.05）;the latency and amplitude of potential P300 patients in the observation group,higher than that of control group（P〈0.05）;the level of eye movement in the observation group higher than that in the control group（P〈0.05）. Conclusion The use of modified electroconvulsive therapy in children with schizophrenia is ideal and worthy of popularization and application.

关 键 词：儿童精神分裂症 无抽搐电休克 利培酮 认知功能 

分 类 号：R749.94[医药卫生—神经病学与精神病学]