雷米芬太尼与芬太尼对行立体定向脑核团射频热凝术精神分裂症患者麻醉效果的对比  

Comparison of remifentanil and fentanyl in the efficacy of stereotactic radiofrequency thermocoagulation of brain nuclei for patients with schizophrenia

作　　者：李慧芳[1] 张联 祝晓娟[1] 田明[1] LI Huifang;ZHANG Lian;ZHU Xiaojuan(Department of Anesthesiology in the First People ~s Hospital of Kashi District,Kashi 844000,China)

机构地区：[1]喀什地区第一人民医院,喀什844000

出　　处：《国际精神病学杂志》2018年第4期689-692,共4页Journal Of International Psychiatry

摘　　要：目的探讨雷米芬太尼与芬太尼对拟行立体定向脑核团射频热凝术的精神分裂症患者麻醉效果的对比研究。方法选自我院于2014年1月~2015年12月期间收治的行立体定向脑核团射频热凝术精神分裂症患者80例。按照随机数字表法分为雷米芬太尼组40例与芬太尼组40例。雷米芬太尼组给予雷米芬太尼麻醉,芬太尼给予芬太尼麻醉。结果雷米芬太尼组插管后、切皮时收缩压(SBP)和舒张压(DBP)较麻醉前降低,有统计学差异(P<0.05);芬太尼组插管后、切皮、睁眼时SBP和DBP较麻醉前增加,有统计学差异(P<0.05);雷米芬太尼组插管后、切皮、睁眼时SBP和DBP低于同期芬太尼组,有统计学差异(P<0.05);雷米芬太尼组插管后、切皮时心率较麻醉前降低,有统计学差异(P<0.05);芬太尼组插管后、切皮、睁眼时心率较麻醉前增加,有统计学差异(P<0.05);雷米芬太尼组插管后、切皮、睁眼时心率低于同期芬太尼组,有统计学差异(P<0.05);雷米芬太尼组术后认知功能恢复时间和停药至睁眼时间快于芬太尼组,有统计学差异(P<0.05)。结论雷米芬太尼对行立体定向脑核团射频热凝术的精神分裂症患者麻醉效果优于芬太尼组。Objective To compare the efficacy of remifentanil and fentanyl in the treatment of schizophrenic patients undergoing stereotactic radiofrequency thermocoagulation of brain nuclei. Methods We selected 80 patients with schizophrenia treated by stereotactic radiofrequency thermocoagulation of brain nuclei in our hospital from January 2014 to December 2015. The patients were divided into the remifentanil group and the fentanyl group according to the random number table with 40 patients in each group. Remifentanil group was given remifentanil for anesthesia,fentanyl was given fentanyl for anesthesia. Results The remifentanil group decreased after intubation,skin incision in SBP and DBP than those before anesthesia,there were significant differences（P〈0.05）;The SBP and DBP in the fentanyl group after intubation,skin incision,eyes open were increased than those before anesthesia,there were significant differences（P〈0.05）;The SBP and DBP in the remifentanil group after intubation,skin incision,eyes open were lower than those in the fentanyl group,there was significantly different（P〈0.05）;The HR in the remifentanil group after intubation,skin incision were lower than those before anesthesia,there was significantly different（P〈0.05）;The HR in the fentanyl group after intubation,skin,eyes open were increased than those before anesthesia,with statistical difference（P〈0.05）;The HR in the remifentanil group after intubation,skin incision,eyes open were lower than those in the fentanyl group,with significant differencse（P〈0.05）;The postoperative cognitive function recovery time and drug withdrawal until eyes opening time in the remifentanil group were faster than those in the fentanyl group,there were statistical different（P〈0.05）. Conclusion Remifentanil is superior to fentanyl in the treatment of schizophrenia patients undergoing stereotactic radiofrequency thermocoagulation of brain nuclei for anesthesia.

关 键 词：雷米芬太尼 芬太尼 精神分裂症 麻醉效果 立体定向脑核团射频热凝术 

分 类 号：R749.3[医药卫生—神经病学与精神病学]