急性脑梗死患者血清脂蛋白相关磷脂酶A2与颅内动脉狭窄的关系研究  

Relationship between serum lipoprotein-related phospholipase A2 and intracranial artery stenosis in patients with acute cerebral infarction

作　　者：张翼[1] 廖远高[1] ZHANG Yi;LIAO Yuangao(Department of Neurology 3,the First People＇s Hospital of Chenzhou City,Chenzhou 423000,China)

机构地区：[1]郴州市第一人民医院神经内科三区,湖南郴州423000

出　　处：《中国实用神经疾病杂志》2018年第15期1712-1717,共6页Chinese Journal of Practical Nervous Diseases

摘　　要：目的观察急性期脑梗死患者血清中脂蛋白相关磷脂酶A2(Lp-PLA2)的水平,并探讨其与颅内动脉狭窄的关联性。方法选择郴州市第一人民医院住院的急性脑梗死患者83例,根据头部CT血管造影(CTA)检查结果将患者分为无颅内动脉狭窄组和颅内动脉狭窄组。选择40例非心脑血管病患者作为对照组。所有患者收集一般资料和吸烟、饮酒等危险因素资料,并进行Lp-PLA2、C反应蛋白、红细胞沉降率、血脂、同型半胱氨酸等实验室相关检查。将各组间的数据进行比较。结果脑梗死组的Lp-PLA2水平明显高于对照组,脑梗死患者中动脉狭窄组的Lp-PLA2水平明显高于无动脉狭窄组。高血压、糖尿病和Lp-PLA2水平是颅内动脉狭窄的危险因素。结论 Lp-PLA2与颅内动脉狭窄密切相关,可作为急性脑梗死和颅内动脉狭窄的风险预测指标。Objective To observe the serum levels of lipoprotein associated phospholipase A2 （Lp- PLA2） in patients with acute cerebral infarction and to explore its association with intracranial artery stenosis. Methods Eighty three patients with acute cerebral infarction admitted to the First People＇s Hospital of Chenzhou were selected. According to the results of CT angiography （CTA）, the patients were divided into the group without intracranial artery stenosis group and the intracranial artery stenosis group. Forty patients without cardiovascular disease were also chose as control group. All patients collected general data and risk factors such as smoking and drinking,and performed laboratory related tests such as Lp PLA2,C reactive protein, erythrocyte sed imentation rate, blood lipids,and homocysteine. Compare the data between the groups. Results The level of Lp PLA2 in the cere bral infarction group was significantly higher than that in the control group（P〈0.05） ,and the level of Lp PLA2 in the intracranial artery stenosis group was significantly higher than that of the non intracranial artery stenosis group（P〈0.05）. Hypertension,alia betes and serum Lp PLA2 level are risk factors for intracranial artery stenosis. Conclusion Lp PLA2 is closely related to intracra nial artery stenosis and can be used as a predictor of risk for acute cerebral infarction and intracranial artery stenosis.

关 键 词：血清脂蛋白相关磷脂酶A2 动脉粥样硬化 脑梗死 颅内动脉狭窄 CT血管造影 

分 类 号：R743.3[医药卫生—神经病学与精神病学]