应用博来霉素行超选择性肝动脉栓塞术治疗肝血管瘤  

Super-selective hepatic artery embolization and bleomycin in treatment of liver hemangioma

作　　者：袁冰 张金龙[2] 袁凯[1] 王燕[1] 阎洁羽[1] 付金鑫 王茂强[1] Yuan Bing;Zhang Jinlong;Yuan Kai;Wang YaM;YaM Jieyu;Fu Jinxin;Wang Maoqiang(Department of ln-terventional Radiology,PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院介入放射科,北京100853 [2]南开大学医学院

出　　处：《中华肝胆外科杂志》2018年第8期510-513,共4页Chinese Journal of Hepatobiliary Surgery

摘　　要：目的探讨应用博来霉素行超选择性肝动脉栓塞术（TAE）治疗肝血管瘤的安全性及长期疗效。方法回顾性分析2011年1月-2014年12月于解放军总医院介入放射科行TAE治疗的132例肝血管瘤患者临床资料。其中男26例，女106例，年龄29．0—65．0（46．0±8．0）岁。栓塞方案采用碘油-博来霉素乳剂＋聚乙烯醇微球。观察入组患者手术相关并发症，术后3、7天肝功能，TAE术前及术后6、12、24、36个月瘤体大小。结果入组患者均成功行TAE，无严重并发症发生。术后随访3～6年瘤体直径较术前显著减少，差异有统计学意义（P〈0．05）。术后6、12、24和36个月临床有效率分别为100％、100％、96．9％和90．6％。结论应用碘油-博来霉素乳剂＋聚乙烯醇微球行TAE治疗肝血管瘤安全、有效，长期疗效可靠。Objective To evaluate the long-term efficacy and safety of super-selective hepatic artery embolization （TAE） and bleomycin hydrochloride in treatment of liver hemangioma. Methods A retrospec- tive analysis was conducted on 132 patients treated for liver hemangioma from January 2011 to December 2014. The patients underwent super-selective TAE. There were 26 men and 106 women. The age ranged from 29.0 to 65.0 （46.0＋ 8.0） years. An emulsion of iodized oil and bleomycin and polyvinyl alcohol particle （PVA） was used for the TAE. Routine follow-up visits on post-treatment Days 3 and 7 were carried out to detect complications and changes in liver function. The diameters of the lesions pre-TAE and at 6, 12 and ev- ery 12 months thereafter were monitored. Results TAE was technically successful in all these patients. The range of follow-up was 3-6 years. The successful rates of treatment at 6 month, 12 months, 24 months, and 36 months, were 100%, 100%, 96.9% and 90.6%, respectively. Conclusion TAE with an emulsion of iodized oil and bleomycin and PVA was a safe and efficacious treatment for liver hemangioma on long-term follow-up.

关 键 词：肝血管瘤 肝动脉栓塞术 血管造影术 数字减影 

分 类 号：R735.7[医药卫生—肿瘤]