基于新技术的胃癌药物疗效的精准评价  

The technological advance in precisely therapeutic evaluation in gastric cancer

作　　者：沈琳[1] 李一林[1] 高静[1] 李艳艳[1] 王小娟 SHEN Lin;LI Yi-lin;GAO Jing;LI Yan-yan;WANG Xiao-juan(Department of Gastrointestinal Oncology,Key Laboratory of CarciniSgenesis and Translational Research（Ministry of Education）,Peking University Cancer Hospital ＆ Institute,Beijing 100142,China)

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所消化肿瘤内科恶性肿瘤发病机制及转化研究教育部重点实验室,北京100142

出　　处：《肿瘤综合治疗电子杂志》2018年第2期52-57,共6页Journal of Multidisciplinary Cancer Management(Electronic Version)

基　　金：国家重点研发计划项目(2017YFC1308900);国家自然科学基金面上项目(81472789);北京市自然科学基金重点项目(7161002)

摘　　要：胃癌的生物学特征通常具有高度的时间和空间异质性,且其转移途径极其复杂。因此,针对胃癌临床疗效进行精准评价及监测显得尤为必要。然而,过去几年间,相对于其他瘤种,针对胃癌疗效的精准评价方法仍然非常有限,且其空腔脏器的生物学特征也使得传统影像学评效技术面临挑战。本文将从医学影像学技术发展、组织水平以及血液水平的药物疗效精准评价等层面,评述新的前沿临床药物疗效精准评价体系,并藉由其他瘤种扩展至胃癌,综述新技术体系的应用范畴和前景。Gastric cancer （GC） always exhibits highly temporal and spatial heterogeneity, with multiple metastatic pathways. Therefore, it is particularly necessary in GC to precisely evaluate and monitor therapeutic efficiency following clinical treatments. Nevertheless, traditional anatomical imaging techniques have been regarded as being of limited value in GC due to the hollow organ. On the other hand, advanced strategies developed for efficacy evaluation in GC is also limited in comparison with other human malignancies. In this paper, advanced technologies developed mainly in medical imaging, histological level and liquid biopsy and their application in precisely efficacy evaluation in GC and other tumors were systematically reviewed.

关 键 词：胃癌 疗效 精准评价 影像学 单细胞组学 液体活检 

分 类 号：R735.2[医药卫生—肿瘤]