泌尿系统淋巴瘤16例临床分析并文献复习  

Urinary tract lymphoma： a clinical analysis of 16 cases and review of literature

作　　者：吴强[1] 桂亚平[1] 丁懿[2] 陈毓华[2] 傅建非[2] 梁爱斌[2] 修冰[2] Wu Qiang;Gui Yaping;Ding Yi;Chen Yuhua;Fu Jianfei;Liang A ibin;Xiu Bing(Department of Uralogy,Tonal Hospital of Tongji University,Shanghai 200065,Chin;Department of Hematology,Tonal Hospital of Tonal University,Shanghai 200065,China)

机构地区：[1]同济大学附属同济医院泌尿科,上海200065 [2]同济大学附属同济医院血液科,上海200065

出　　处：《白血病．淋巴瘤》2018年第6期348-352,共5页Journal of Leukemia & Lymphoma

基　　金：国家自然科学基金青年基金（81600156）;上海申康医院发展中心新兴前沿技术项目（SHDC12015108）

摘　　要：目的 探讨泌尿系统淋巴瘤患者的临床特征、治疗效果及预后.方法 回顾性分析同济大学附属同济医院2009年1月至2016年4月收治的16例泌尿系统淋巴瘤患者的临床资料,对其临床特点、诊治经过及预后进行分析.结果 16例患者中位发病年龄68岁,其中14例以泌尿系统症状起病,10例影像学检查提示泌尿系统肿块.淋巴瘤起病部位：肾脏4例,肾上腺5例,睾丸5例,前列腺及尿道外口各1例.12例病理类型为弥漫大B细胞淋巴瘤,以非生发中心为主;12例Ann Arbor临床分期为ⅢE~ⅣE期;10例国际预后指数（IPI）评分≥3分;7例伴有B症状;10例患者通过手术确诊;14例接受含利妥昔单抗方案的化疗.初治完全缓解5例,部分缓解3例.结论 泌尿系统淋巴瘤患者诊断时多为晚期,病变侵袭性强.患者病理类型以弥漫大B细胞淋巴瘤为主,治疗主要采取手术联合放化疗,初治完全缓解率低,应重视早期诊断及治疗.Objective To analyze the clinical features, treatment outcomes and prognosis of patients with urinary tract lymphoma. Methods The clinical data of 16 patients in Tongji Hospital of Tongji University from January 2009 to April 2016 were collected and retrospectively analyzed. Results The median age of these patients was 68 years. The onset symptoms of 14 cases were related to urinary system and imaging studies of 10 cases showed masses in the urinary system. The onset regions of lymphoma included：4 cases were renal lymphoma, 5 cases were adrenal lymphoma, 5 cases were testicular lymphoma, 1 case was prostate lymphoma and 1 case was from urethral mouth. The histological type of 12 cases was diffuse large B-cell lymphoma and 10 patients were non-germinal center B cell-like （non-GCB） molecular profiling. Twelve cases belonged to Ann Arbor stages ⅢE- ⅣE, 10 cases had international prognostic index scores ≥3, and 7 cases had B symptoms. 10 patients were confirmed by surgery. Fourteen cases accepted rituximab-containing regimen chemotherapy. Five cases achieved complete response and 3 were partial response. Conclusions The clinical manifestations and imagine examination of patients with urinary tract lymphoma are lack of specificity. The clinical features are highly aggressive and most of the patients are diagnosed at advanced stage. The main histological type is diffuse large B-cell lymphoma and non-GCB molecular profiling. Treatment regimens include surgery combined with chemotherapy and radiotherapy. Earlier diagnosis and treatment may improve the survival of patients.

关 键 词：泌尿系肿瘤 淋巴瘤 治疗 

分 类 号：R737.1[医药卫生—肿瘤]