血小板、纤维蛋白原、D-二聚体与溃疡性结肠炎相关性的研究  

Study on Correlation Between Platelet,Fibrinogen,D-Dimer and Ulcerative Colitis

作　　者：王大秀 韩继武[1] FANG Daxiu;HAN Jiwu(Department of Gastroenterology,the Fourth Affiliated Hospital of Harbin Medical University,Harbin（150001)

机构地区：[1]哈尔滨医科大学附属第四医院消化内科,150001

出　　处：《胃肠病学》2018年第8期486-488,共3页Chinese Journal of Gastroenterology

摘　　要：背景:越来越多研究发现溃疡性结肠炎(UC)患者胃肠系统存在高凝状态和炎症反应,但与血小板(PLT)、纤维蛋白原(FIB)和D-二聚体水平的相关性尚不明确。目的:探讨PLT、FIB、D-二聚体与UC的相关性。方法:收集2015年8月—2017年10月哈尔滨医科大学附属第四医院收治的85例UC患者,根据改良Mayo评分将患者分为活动期和缓解期,活动期患者又分为轻度、中度、重度组,以53名健康志愿者作为对照。比较外周血PLT、FIB、D-二聚体水平,并分析其与UC分期、疾病严重程度、C-反应蛋白(CRP)和红细胞沉降率(ESR)水平的相关性。结果:活动期、缓解期、对照组PLT、FIB、D-二聚体、CRP、ESR水平依次降低(P<0.05)。轻度组PLT、FIB、D-二聚体、CRP、ESR水平均显著低于中度组、重度组(P<0.05),中度组FIB、D-二聚体、CRP水平均显著低于重度组(P<0.05)。Spearman相关性分析显示,PLT、FIB、D-二聚体与UC分期、疾病严重程度、CRP、ESR均呈正相关(P<0.05)。结论:PLT、FIB和D-二聚体与UC分期和疾病严重程度呈正相关,可作为反映UC分期和疾病严重程度的参考指标。Background： More and more studies have found that hypercoagulable state and inflammatory reaction exist in the gastrointestinal system of patients with ulcerative colitis （UC）,however,the correlation with platelet （PLT）,fibrinogen （FIB） and D-dimer levels is unclear. Aims： To investigate the correlation of PLT,FIB,D-dimer with UC. Methods：Eighty-five UC patients from August 2015 to October 2017 at the Fourth Affiliated Hospital of Harbin Medical University were enrolled,and were divided into active UC and remission UC according to modified Mayo scoring system,and active UC were further divided into mild,moderate and severe groups. Fifty-three healthy subjects were served as controls. Levels of peripheral blood PLT,FIB,D-dimer were compared,and their correlations with C-reactive protein （CRP） and erythrocyte sedimentation rate （ESR） were analyzed. Results： Levels of PLT,FIB,D-dimer,CRP and ESR were gradually decreased from active UC group,remission UC group to control group （P〈0. 05）. The levels of PLT,FIB,Ddimer,CRP and ESR were significantly decreased in mild group than in moderate group and severe group （P〈0. 05）. The levels of FIB,D-dimer and CRP were significantly decreased in moderate group than in severe group （P〈0. 05）.Spearman correlation analysis showed that PLT,FIB,D-dimer were positively correlated with staging,severity of UC,CRP and ESR （P〈0. 05）. Conclusions： PLT,FIB and D-dimer are positively correlated with staging,severity of UC,and can be used as indices reflecting staging,severity of UC.

关 键 词：结肠炎 溃疡性 血小板 纤维蛋白原 D-二聚体 

分 类 号：R574.62[医药卫生—消化系统]