丁苯酞对血管源性轻度认知障碍患者认知功能及脑血流量的影响  

Effects of Butylphthalide on Cognitive Function and Cerebral Blood Flow in Patients with Vascular Mild Cognitive Impairment

作　　者：宋天琦[1] Song Tianqi(Affiliated Hospital of Beihua University,Jilin 132011,China)

机构地区：[1]北华大学附属医院,吉林吉林132011

出　　处：《北华大学学报（自然科学版）》2018年第5期630-633,共4页Journal of Beihua University（Natural Science）

基　　金：吉林市科技计划项目(201437003)

摘　　要：目的观察丁苯酞治疗血管源性轻度认知障碍患者的疗效及其对认知功能及脑血流量的影响.方法选取92例血管源性轻度认知障碍患者作为研究对象,采用系统抽样法将患者分为对照组和研究组,每组46例.给予对照组患者吡拉西坦治疗,给予研究组患者丁苯酞治疗,对两组患者的临床疗效、不良反应、治疗前后认知功能及脑血流速度进行观察分析.结果两组患者疗效比较研究组优于对照组(P<0.05);两组患者的不良反应比较差异无统计学意义(P>0.05);两组患者治疗前认知功能及脑血流速度比较差异无统计学意义(P>0.05);两组患者治疗后认知功能及脑血流速度比较研究组优于对照组(P<0.05).结论应用丁苯酞治疗血管源性轻度认知障碍,临床疗效明确.Objective To investigate the effect of butheptidine on cognitive function and cerebral blood flow in the treatment of patients with vascular mild cognitive impairment. Method A total of 92 patients with vascular mild cognitive impairment were selected as subjects. The systematic sampling method was used to divide the patients into two groups： control group and study group,46 cases in each group. The patients in the control group were treated with piracetam,and patients in the study group were treated with butylphthalide. Clinical efficacy,adverse reactions,cognitive function before and after treatment,and cerebral blood flow velocity were observed and analyzed in both groups. Results The curative effect of the study group was statistically better than that of the control group（ P〈0.05）. There was no significant difference in adverse reactions between the two groups（ P〈0.05）. Comparing the cognitive function and cerebral blood flow velocity before treatment between the two groups,there was no significant difference（ P〈0.05）. Comparing the cognitive function and cerebral blood flow velocity after treatment between the two groups,the study group was superior to the control group,and the difference between the two groups was statistically significant（ P〈0.05）. Conclusion Butylphthalide has a good effect on cognitive function and cerebral blood flow in the treatment of patients with vascular mild cognitive impairment. Its clinical curative effect is clear and worthy of clinical application.

关 键 词：丁苯酞 血管源性轻度认知障碍 认知功能 脑血流量 

分 类 号：R749.1[医药卫生—神经病学与精神病学]