自拟健脾补肾方对结直肠癌肝转移患者血清MMP-9、TIMP-1的影响  

Effects of Jianpi Bushen Recipe on Serum MMP-9 and TIMP-1 Levels in Patients with Liver Metastases from Colorectal Cancer

作　　者：葛少华[1] 孔凡萍[1] 邓正明[1] 潘超 曹仕兵[1] GE Shaohua;KONG Fanping;DENG Zhengming;PAN Chao;CAO Shibing(General Surgical Department,Jiangsu Province Hospital of TCM,Nanjing,Jiangsu,210029,China)

机构地区：[1]江苏省中医院普外科,江苏南京210029

出　　处：《肿瘤药学》2018年第4期569-573,共5页Anti-Tumor Pharmacy

基　　金：国家自然科学基金面上项目(81470197)

摘　　要：目的探讨自拟健脾补肾方对结直肠癌肝转移患者血清MMP-9、TIMP-1的影响。方法将82例结直肠癌肝转移患者分为观察组和对照组。对照组采用常规FOLFOX4方案化疗。观察组在对照组的基础上联合自拟健脾补肾方治疗。采用RECIST实体瘤标准评估两组的临床疗效;检测两组治疗前后血清MMP-9、TIMP-1水平;采用欧洲癌症治疗研究组织制定的生存质量测定量表(QLQ-C30)评估两组患者的生存质量。结果观察组的控制率高于对照组,差异有统计学意义(P<0.05);两组的缓解率无明显差异(P>0.05);两组治疗后血清MMP-9、TIMP-1水平明显降低,QLQ-C30评分明显升高(P<0.05);观察组治疗后血清MMP-9水平低于对照组,血清TIMP-1水平和QLQ-C30评分高于对照组,差异均有统计学意义(P<0.05);观察组恶心呕吐、白细胞减少、肝功能损伤、肾功能损伤、血小板减少的发生率均低于对照组,差异有统计学意义(P<0.05)。结论自拟健脾补肾方可提高结直肠癌肝转移的疗效,改善血清MMP-9、TIMP-1水平,降低不良反应发生率。Objective To investigate the effects of self-made Jianpi Bushen Recipe on serum MMP-9 and TIMP-1 in patients with liver metastases from colorectal cancer. Methods A total of 82 patients with liver metastases from colorectal cancer were divided into observation group and control group. The control group was treated by FOLFOX4 chemotherapy. The observation group was treated with Jianpi Bushen Recipe on the basis of the control group. The RECIST solid tumor standard was applied to evaluate the clinical efficacy of the two groups. Serum levels of MMP-9 and TIMP-1 were measured before and after treatment in two groups. The quality of life （QOL） changes of the two groups were assessed by the quality of life scale （QLQ-C30） developed by the European cancer treatment research institute. Results The control rate of the observation group was higher than that of the control group. The difference was statistically significant （P 〈 0.05）. There was no significant difference in the rate of remission between the two groups （P〉0.05）. After treatment, the serum levels of MMP-9 and TIMP-1 decreased significantly and QLQ-C30 scores increased significantly in the two groups （P 〈 0.05）. The MMP-9 level of the observa- tion group after treatment was lower than that of the control group, but the TIMP-1 level and QLQ-C30 scores were higher than those of the control group with statistical differences （P〈0.05）. During treatment, the incidence rates of nausea and vomiting, leukocyte reduction, liver function impairment, renal function impairment and thrombocytopenia in the observation group were all lower than those in the control group （P 〈 0.05）. Conclusion Jianpi Bushen recipe could strengthen the curative effect of liver metastases from colorectal cancer, improve the lev- els of serum MMP-9 and TIMP-1, and reduce the occurrence of adverse reactions.

关 键 词：自拟健脾补肾方 直肠癌肝转移 MP-9 TIMP-1 不良反应 

分 类 号：R735.3[医药卫生—肿瘤]