APRI值与伴HBsAg^+结直肠癌患者同时性肝转移的相关性分析  

Correlation between aminotransferase-to-platelet ratio index value and synchronous liver metastasis in colorectal cancer patients with HBsAg^+

作　　者：霍婷婷[1,2] 贾荣霞 田耀文 曹景玉 张明智[1] 赵磊[1,2,4] Huo Tingting;Jia Rongxia;Tian Yaowen;Cao Jingyu;Zhang Mingzhi;Zhao Lei(Department of Oneology,the First Ajfiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Hepatobiliary Surgery,the Shandong Cancer Hospital,Jinan 250117,China;Dezhou Municiple Hospital,Dezhou 253000,China;Shandong Academy of Medical Sciences,Jinan 250200,China;Depart,wnt of Hepatobiliary Surgery,the Affiliated Hospital of Qingdao University,Qingdao 266555,China)

机构地区：[1]郑州大学第一附属医院肿瘤科,河南郑州450052 [2]山东省肿瘤医院肝胆外科,山东济南250117 [3]德州市立医院,山东德州253000 [4]山东省医学科学院,山东济南250200 [5]青岛大学附属医院肝胆外科,山东青岛266555

出　　处：《河南医学研究》2018年第14期2511-2513,共3页Henan Medical Research

基　　金：山东省医学科学院2015青年创新项目

摘　　要：目的评价天冬氨酸转氨酶/血小板比值指数(aspartate transaminase and platelet ratio,APRI)与伴乙肝表面抗原阳性(HBs Ag^+)结直肠癌患者同时性肝转移之间的相关性。方法回顾性分析青岛大学附属医院和山东省肿瘤医院2010年1月至2016年1月收治的214例伴有HBs Ag^+初诊结直肠癌患者的完整病历资料。按是否发生同时性肝转移将214例患者分成两组,syn CRLM^+组30例(同时性肝转移组)和syn CRLM-组184例(无同时性肝转移组),分析APRI值与同时性肝转移的相关性。按APRI值将患者分成两组,APRI高水平组(APRI>0.5)和APRI低水平组(APRI≤0.5),比较两组同时性肝转移率。结果 syn CRLM^+组APRI值低于syn CRLM-组,差异有统计学意义(P<0.05),两组患者性别、年龄、分化程度等差异均无统计学意义(P>0.05)。APRI高水平组同时性肝转移率低于APRI低水平组,差异有统计学意义(P<0.05)。结论伴HBs Ag^+的结直肠癌患者中,高水平APRI者发生同时性肝转移的概率小于低水平APRI者。Objective To evaluate the association between anfinotransferase to platelet ratio index（APRI） and synchro nous liver metastasis in patients with colorectal cancer with HBsAg ＋ . Methods The complete medical records of 214 patients with HBsAg ＋ newly diagnosed colorectal cancer admitted to the Affiliated Hospital of Qingdao University and Shandong Cancer Hospital from January of 2010 to January of 2016 were retrospectively analyzed. Patients were divided into the synCRLM ＋ group （sinmltaneous liver metastasis group, 30 cases） and the synCRLM group （no concurrent liver metastasis group, 180 cases） ac- cording to whether concurrent liver metastases occurred. The APRI and rate of synchronous liver metastases were analyzed. Pa- tients were divided into APRI high - level group （ APRI 〉 0. 5 ） and APRI low - level group （ APRI ~〈 0. 5 ） according to APRI values, and the rates of synchronous liver metastases were analyzed between two groups. Results The APRI value of synCRLM ＋ group was lower than that of synCRLM group, the difference was statistically significant （P 〈 0. 05 ）. There was no significant difference in gender, age and differentiation between two groups （P 〉0. 05 ）. The rate of synchronous liver metastases in the APRI high - level group was lower than that in the APR1 - low group, and the difference was statistically significant （ P 〈 0. 05 ）. Conclusion Among colorectal cancer patients with HBsAg ＋ , the probability of concurrent liver metastasis in patients with high -level APRI is lower than that in patients with low -level APRI.

关 键 词：结直肠癌 同时性肝转移 肝硬化 天冬氨酸转氨酶/血小板比值指数 乙型肝炎表面抗原 

分 类 号：R735.3[医药卫生—肿瘤]