分子蒸馏技术提纯双三氟虫脲关键中间体2-氯-3,5-二(三氟甲基)苯胺工艺研究  

Study on Refining of 2-Chloro-3,5-bis(trifluoromethyl) aniline by Molecular Distillation

作　　者：刘玮 杨帆 邢冰梅 毛龙飞[3] 姜玉钦[3] LIU WEI1, YANG Fan2, XING Bing-mei1, MAO Long-fei3, JIANG Yu-qin3.(1. China pharmaceutical health industry co. LTD, Beijing 100061, China; 2. Henan Institute of Geological Survey, Henan Zhengzhou 450000, China; 3. Henan Normal University, Henan Xinxiang 453007, China)

机构地区：[1]中国医药健康产业股份有限公司,北京东城区100061 [2]河南省地质调查院,河南郑州450000 [3]河南师范大学化学化工学院,河南新乡453007

出　　处：《当代化工》2018年第8期1553-1555,1559,共4页Contemporary Chemical Industry

基　　金：2015年度河南省重点科技攻关项目;项目号:152102210285

摘　　要：采用2英寸刮膜分子蒸馏设备对双三氟虫脲关键中间体2-氯-3,5-二(三氟甲基)苯胺的提纯进行研究,考察了多种分离工艺参数对2-氯-3,5-二(三氟甲基)苯胺纯度和收率的影响,得到了最佳工艺条件:蒸馏温度为80℃,真空度为5 Pa,刮膜器转速450 r·min-1,产品纯度和收率分别达到96.9%和65.4%,该工艺具有操作简单,分离效果好,适合工业化生产等优点。Wiped film molecular distillation device was used in the study of 2-chloro-3,5-bis（trifluoromethyl）aniline purification, and the effect of separating parameters on the purity and yield was investigated. The optimum molecular distillation process was achieved at 80 ℃with the scraper speed of 450 r·min-1 and vacuum of 5 Pa. Under such optimum conditions, the purity and yield were 96.9% and 65.4%, respectively. This process has the advantages of simple operation and effective separation, and is suitable for industrial production.

关 键 词：分子蒸馏 2-氯-3 5-二(三氟甲基)苯胺 工业化生产 

分 类 号：TQ453[化学工程—农药化工]