精神分裂症患者认知功能损害的影响因素  

Influencing factors of cognitive impairment in schizophrenic patients

作　　者：葛传惠 宋红涛 曹迎春 赵婷婷 李淑彦 窦丽丽 翟长平[1] GE Chuanhui;SONG Hongtao;CAO Yingchun;ZHAO Tingting;LI Shuyan;DOU Lili;ZHAI Changping(Anhui Province Veterans Hospital,Bengbu Anhui 233400,China;Bengbu Medical College)

机构地区：[1]安徽省荣军医院,安徽蚌埠233400 [2]蚌埠医学院

出　　处：《中国民康医学》2018年第16期1-3,7,共4页Medical Journal of Chinese People’s Health

基　　金：蚌埠医学院自然科学基金重点课题(项目编号BYKY1616ZD)

摘　　要：目的:探讨精神分裂症患者认知功能损害的影响因素。方法:选取81例精神分裂症患者(为观察组)及40名健康人(为对照组),比较两组重复性成套神经心理状态测验量表(RBANS)评分,分析其影响因素,对各影响因素进行Pearson相关性分析。结果:观察组RBANS量表总分及即刻记忆、视觉广度、言语功能、注意、延时记忆得分均明显低于对照组,差异有统计学意义(P<0.05)。不同性别、婚姻、临床分型、病程,有无职业、家族史的精神分裂症患者RBANS总分及5个因子分差异无统计学意义;不同年龄患者仅视觉广度评分比较差异有统计学意义(P<0.05);不同学历患者RBANS量表总分及言语功能、注意、即刻记忆、延时记忆因子分比较差异均有统计学意义(P<0.05);不同住院次数患者言语功能评分比较差异有统计学意义(P<0.05)。Pearson相关分析显示,年龄与视觉广度呈负相关(P<0.05),学历与即刻记忆、注意、延时记忆及RBANS总分均呈正相关(P<0.01),住院次数与言语功能、注意均呈负相关(P<0.05)。结论:年龄、住院次数、学历是精神分裂症患者认知功能损害的影响因素。Objective： To investigate influencing factors of cognitive impairment in schizophrenic patients. Methods： 81 patients with schizophrenia（observed group） and 40 healthy people（control group） were selected. The scores of repeatable battery for the assessment of neuropsychological status（RBANS） of the two groups were compared,and the influencing factors of cognitive impairment were analyzed. The Pearson correlation analysis was performed. Results： The total score of the RBANS scale and the scores of the immediate memory,visual breadth,speech function,attention,and delayed memory of the observation group were significantly lower than those of the control group,and the differences were statistically significant（P〈0.05）. There were no significant differences in the total RBANS score and 5 factor scores among the patients with different gender,marriage,clinical classification,course of disease,and occupational or family history of schizophrenia. The differences in the visual breadth score among the patients of different ages were significant（P〈0.05）. Further,there were significant differences in the total RBANS score and the scores of speech function,attention,immediate memory and delayed memory among the patients with different education backgrounds were statistically different（P〈0.05）,and there were statistically significant differences in the speech function score among the patients with different hospitalizations（P〈0.05）. The Pearson correlation analysis showed that age and visual breadth were negatively correlated（P〈0. 05）,education background and immediate memory,attention,delayed memory were positively correlated（P〈0.01）,and the number of hospitalization and speech function,attention were negatively correlated（P〈0.05）. Conclusions： Age,hospitalization times,and education background are factors influencing cognitive impairment in the patients with schizophrenia.

关 键 词：精神分裂症 认知功能 影响因素 

分 类 号：R749.3[医药卫生—神经病学与精神病学]