PRR11在肝癌中的表达及其与预后的关系  

Expression of Proline Rich Protein 11 in Hepatocellular Carcinoma and Its Relationship with Prognosis

作　　者：祁馨卉[1] 栾玉婷[2] 韩涛[1] 杨晓丹[1] 李清[2] 郑振东[1] QI Xin-hui;LUAN Yu-ting;HAN Tao;YANG Xiao-dan;LI Qing;ZHENG Zheng-dong(The General Hospital of Shenyang Military Command,Shenyang 110016,China;Clinical Department of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)

机构地区：[1]沈阳军区总医院,辽宁沈阳110016 [2]沈阳药科大学临床药学系,辽宁沈阳110016

出　　处：《肿瘤学杂志》2018年第8期769-773,共5页Journal of Chinese Oncology

基　　金：中国博士后科学基金面上项目(2015M582822);辽宁省博士科研启动基金(201501022);军队医学科技青年培育计划(15QNP005)

摘　　要：[目的]研究肝癌组织中富含脯氨酸蛋白11（PRR11）表达与肝癌临床病理参数之间的关系,以及PRR11表达对肝癌患者预后的影响。[方法]通过构建含243例肝癌的组织芯片,用免疫组化方法检测PRR11蛋白在肝癌组织中的表达。[结果]243例肝癌组织标本中,PRR11高表达与性别、AFP水平、HBSAg、HBeAg水平有关。Kaplan-Meier生存分析显示：PRR11高表达患者总生存期短于低表达患者（36.5个月vs46.3个月,P=0.007）,且病理分期（Ⅰ~ⅡvsⅢ~Ⅳ：60.7个月vs19.5个月,P=0.001）、主瘤直径（≤5cmvs〉5cm：55.9个月vs19.5个月,P〈0.001）、有无癌栓（无vs有：49.3个月vs22.7个月,P〈0.001）、子灶数目（≤1个vs〉1个：50.0个月vs22.5个月,P〈0.001）与总生存期均显著相关。Cox风险回归模型分析显示PRR11表达是肝癌患者的独立预后因素（P=0.007）。[结论]PRR11在部分肝癌组织中高表达,是肝癌患者独立的不良预后因素。[Objective] To investigate the expression of proline protein 11（PRR11） in hepatocellular carcinoma（HCC） and its relationship with clinicopathological features and the prognosis of patients with HCC.[Methods] The expression of PRR11 protein was detected by immunohistochemical staining in tissue specimens of 243 HCC patients. [Results] The expression of PRR11 was positively correlated with gender,AFP level,HBs Ag and HBe Ag levels of HCC patients. Kaplan-Meier survival analysis showed that the overall survival（OS） in patients with low PRR11 expression was significantly longer than that in patients with high PRR11 expression（46.3 months vs 36.5 months,P=0.007）. The OS was also significantly correlated with the pathological stage（Ⅰ~Ⅱ vs. Ⅲ~Ⅳ ：60.7 months vs. 19.5 months,P=0.001）,tumor diameter（≤ 5 cm vs〉 5 cm：55.9 months vs 19.5 months,P〈0.001）,tumor embolus（No vs Yes：49.3 months vs 22.7 months,P〈0.001） and number of sub-foci（≤1 vs 〉1：50.0 months vs 22.5 months,P〈0.001）. Cox risk regression model analysis showed that PRR11 expression was an independent prognostic factor for HCC patients. [Conclusion] PRR11 is highly expressed in HCC tissues and is an independent prognostic factor for HCC patients.

关 键 词：PRR11 肝细胞肝癌 预后 

分 类 号：R735.7[医药卫生—肿瘤]