Clinicopathological characterization of gastroenteropancreatic neu-roendocrine neoplasms： a retrospective study of 48 cases  

作　　者：Jianguo Sun Xiaodong Zhang Songjing Lei Jingzhong Xu Zhaoyang Qin 

机构地区：[1]Department of Endocrinae, Rizhao Lanshan District People's Hospital, Rizhao 276826, China [2]Department of Laboratory, The Centers for Disease Control and Prevention of Rizhao, Rizhao 276826, China [3]Department of Imaging, Weihaiwei People's Hospital, Weihai 264200, China [4]Department of Internal medicine, Rizhao Jufeng Central Hospital, Rizhao 276826, China [5]Department of General Surgery, Rizhao People's Hospital, Jining Medical University, Rizhao 276826, China

出　　处：《Oncology and Translational Medicine》2018年第4期163-170,共8页肿瘤学与转化医学（英文版）

基　　金：Supported by a grant from the Jining Medical University Teacher’s Research Support Fund(No.2018)

摘　　要：Objective Gastroenteropancreatic neuroendocrine neoplasms （GEP-NENs） constitute a rare and heterogeneous group of tumors with varied biology and still constitute a diagnostic and therapeutic challenge for physicians of all specialties. In the present study, we aimed to review and study the clinicopathological characteristics of GEP-NENs applying the World Health Organization （WHO） 2010 grading criterion. Methods A total of 48 patients were enrolled in the study. The study included patients diagnosed with GEP-NENs who were treated and followed up at our Hospital from January 2013 to December 2017. Data regarding clinicopathological features of the patients were retrospectively evaluated. The expression of neuroendocrine markers was measured using the immunohistochemical Ultra SensitiveTM S-P method of staining in 48 cases of primary GEP-NENs; and serum levels of neuron-specific enolase, carbohydrate an-tigen 19-9, and carcinoembryonic antigen in 36 GEP-NEN patients were measured using the electrochemiluminescence method. Results The median age at presentation was 59.3 （range 48-82） years, and 39 cases （81.3%） were seen between the 5th and 6th decades. There was a male predilection （male： female=3：1）. In 79.2% cases （38/48）, tumors were hormonally nonfunctional. The most common presentation was abdominal pain, and the most frequent primary site of the tumor was the rectum, followed by the stomach （n = 15, 31.3%）, colon （n = 5, 10.4%）, and so on. Of the 48 tumors, 16 （33.3%） were G1,6 （12.5%） cases were G2, 16 （33.3%） were neuroendocrine carcinoma （NEC）, and 10 （20.8%） were mixed adenoneuroendocrine carcinoma （MANEC）. According to the AJCC/UICC classification, 45.8% （n = 22） were diagnosed at low stage （stage Ⅰ or Ⅱ） while 54.2% （n = 26） were diagnosed at high stage （stage Ⅲ or Ⅳ） （the majority of NEC, G3, and MANEC）. A male preponderance was noted for all tumors except for G2 neoplasms, which showed no gender predilection. ThirtObjective Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs) constitute a rare and heterogeneous group of tumors with varied biology and still constitute a diagnostic and therapeutic challenge for physicians of all specialties. In the present study, we aimed to review and study the clinicopathological characteristics of GEP-NENs applying the World Health Organization(WHO) 2010 grading criterion.Methods A total of 48 patients were enrolled in the study. The study included patients diagnosed with GEP-NENs who were treated and followed up at our Hospital from January 2013 to December 2017. Data regarding clinicopathological features of the patients were retrospectively evaluated. The expression of neuroendocrine markers was measured using the immunohistochemical Ultra Sensitive^(TM) S-P method of staining in 48 cases of primary GEP-NENs; and serum levels of neuron-specific enolase, carbohydrate an-tigen 19-9, and carcinoembryonic antigen in 36 GEP-NEN patients were measured using the electrochemiluminescence method.Results The median age at presentation was 59.3(range 48–82) years, and 39 cases(81.3%) were seen between the 5 th and 6 th decades. There was a male predilection(male: female=3:1). In 79.2% cases(38/48), tumors were hormonally nonfunctional. The most common presentation was abdominal pain, and the most frequent primary site of the tumor was the rectum, followed by the stomach(n = 15, 31.3%), colon(n = 5, 10.4%), and so on. Of the 48 tumors, 16(33.3%) were G1, 6(12.5%) cases were G2, 16(33.3%) were neuroendocrine carcinoma(NEC), and 10(20.8%) were mixed adenoneuroendocrine carcinoma(MANEC). According to the AJCC/UICC classification, 45.8%(n = 22) were diagnosed at low stage(stage I or II) while 54.2%(n = 26) were diagnosed at high stage(stage III or IV)(the majority of NEC, G3, and MANEC). A male preponderance was noted for all tumors except for G2 neoplasms, which showed no gender predilection. Thirty-nine patients underwent endoscopic biopsy. The lesions in 18.8%(n = 9) of the patients were ind

关 键 词：Gastroenteropancreatic neuroendocrine neoplasms （GEP-NENs） Ki 67/MIB-1 index mitotic rate diagnosis PROGNOSIS 

分 类 号：R735[医药卫生—肿瘤]