miR-21在头颈肿瘤中的研究进展  

The Research Progress of miR-21 in Head and Neck Cancer

作　　者：吴淋蓉 郝文娟[1,2] 刘伟红 沈志森 邓红霞[2] Wu Linrong;Hao Wenjuan;Liu Weihong;Shen Zhisen;Deng Hongxia(Ningbo University School of Medicine,Ningbo 315211,China;Ningbo Medical Centre of Lihuili Hospital,Ningbo 315040,China)

机构地区：[1]宁波大学医学院,宁波315211 [2]宁波市医疗中心李惠利医院,宁波315040

出　　处：《中国细胞生物学学报》2018年第8期1438-1444,共7页Chinese Journal of Cell Biology

基　　金：浙江省自然科学基金(批准号:LY14H160003);宁波市科技创新团队(批准号:2012B82019;2015B11050);宁波市重大择优委托项目(批准号:2012C5015);宁波市自然科学基金(批准号:2012A610217);浙江省医药卫生科技计划项目(批准号:2012ZDA042);浙江省医药卫生省部培育计划(批准号:2014PYA017);宁波市医疗卫生品牌学科建设项目资助(批准号:PPXK2018-02)资助的课题~~

摘　　要：微小RNA(micro RNA,miRNA)是一类小分子非编码RNA,可引起靶m RNA的降解或翻译抑制,从而对基因进行转录后表达调控,它在细胞生长、发育和衰老等生命过程中扮演着重要角色。miR-21在人类组织和细胞中较早发现,是广泛存在的miRNA之一,也是实体肿瘤中最常见的过高表达miRNA之一,在肿瘤的发生发展中可能发挥癌基因的作用。该文就miR-21在头颈肿瘤中的研究作一综述。Micro RNA（miRNA） is a kind of small non-coding RNA, which can cause degradation or translation inhibition of target miRNA, and thus, it regulates the expression of genes after transcription. It plays an important role in cell growth, development and aging. miR-21 is one of miRNA which was found earlier and exists extensively in human tissues and cells, and is also one of the most common overexpressed miRNA in solid tumors. It may play a role as an oncogene in the development of tumors. This article reviews the research of miR-21 in head and neck tumors.

关 键 词：头颈肿瘤 MIRNA-21 机制 

分 类 号：R739.91[医药卫生—肿瘤]