52例老年上皮性卵巢癌病人的临床特点及预后相关因素分析  

Clinical characteristics and prognosis of epithelial ovarian cancer in the elderly patients

作　　者：李小钊[1] 应小燕[1] LI Xiao-zhao;YING Xiao-yan(Department of Gynecology and Obstetrics,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China)

机构地区：[1]南京医科大学第二附属医院妇产科,江苏省南京市210011

出　　处：《实用老年医学》2018年第8期737-739,共3页Practical Geriatrics

摘　　要：目的探讨老年上皮性卵巢癌病人的预后相关因素及5年生存率。方法回顾性分析2010~2012年于我院初治的52例上皮性卵巢癌老年病人的临床资料,采用卡方检验进行单因素分析,采用Cox比例风险模型进行多因素分析。结果 52例老年病人的总体5年生存率为42.31%,Ⅰ~Ⅱ期病人的5年生存率明显高于Ⅲ~Ⅳ期病人(P<0.05),分别为84.21%、18.18%;手术残留灶<1 cm的病人5年生存率显著高于残留灶≥1 cm的病人(P<0.05),分别为56.76%、6.67%;化疗疗程≥6个周期的病人5年生存率明显高于化疗疗程<6个周期的病人(P<0.05),分别为50.00%、46.30%。多因素分析结果显示手术分期是老年卵巢癌病人预后的独立影响因素。结论手术分期、残留灶大小、化疗疗程等可影响病人预后,其中手术病理分期是老年上皮性卵巢癌预后的独立影响因素。Objective To investigate the influencing factors of prognosis and 5-year survival rate of epithelial ovarian cancer in the elderly patients. Methods The clinical data of 52 elderly patients with epithelial ovarian cancer in our hospital from January 2010 to December 2012 were retrospectively analyzed. The univariate analysis was performed using chi-square test and Cox proportional hazards model was used for multivariate analysis. Results The overall 5-year survival rate of 52 elderly patients was42. 31%. The 5-year survival rate of the patients with stage Ⅰ-Ⅱ was significantly higher than that of the patients with stage Ⅲ-Ⅳ（ 84. 21% vs. 18. 18%,P〈0. 05）; The 5-year survival rate of the patients with residual lesions 〈1 cm was significantly higher than that the of patients with residual lesions ≥ 1 cm（ 56. 76% vs. 6. 67%,P〈0. 05）; The 5-year survival rate of the patients with ≥ 6 courses of chemotherapy was significantly higher than that of the patients with 〈6 courses of chemotherapy（ 50. 00%vs. 46. 30%,P〈0. 05）. Multivariate analysis showed that surgical staging was an independent factor that influenced the prognosis of elderly patients with ovarian cancer. Conclusions The stage of surgery,the size of residual tumor and the course of chemotherapy can affect the prognosis of patients. The surgical pathological stage is an independent prognostic factor for elderly patients with epithelial ovarian cancer.

关 键 词：上皮性卵巢癌 预后 5年生存率 

分 类 号：R737.31[医药卫生—肿瘤]