肥大细胞在肿瘤血管新生中的作用  

The Function of Mast Cell during Tumor Angiogenesis

作　　者：周晓鹰[1,2] 蒋媛[1] 魏涛[1] ZHOU Xiaoying;JIANG Yuan;WEI Tao(School of Pharmaceutical Engineering and Life Science,Changzhou University,Changzhou 213164,China;The School of Medicine,University of Southampton,Southampton SO16 6YD,UK)

机构地区：[1]常州大学制药与生命科学学院,江苏常州213164 [2]英国南安普顿大学医学院

出　　处：《常州大学学报（自然科学版）》2018年第5期81-86,共6页Journal of Changzhou University：Natural Science Edition

基　　金：常州大学高层次人才引进启动基金(ZMF14020066);常州科技局国际交流研究基金(CZ20150014);英国British Medical Research Council;UK(G0500729)

摘　　要：血管新生是由内皮细胞介导的动态过程,是从已存在的血管结构处形成新的血管,该过程受到血管微环境中促血管生成因子和抗血管生成因子之间平衡的高度调节,并有细胞外基质蛋白,粘附分子和蛋白水解酶的参与,在肿瘤的发生、发展和进程中有着重要的作用。研究表明,肥大细胞是肿瘤浸润的关键的宿主细胞,并且与肿瘤有关的血管新生和肿瘤生长有着密切联系。在病理条件下,肥大细胞激活并释放一系列促血管生成因子,其中包括特异性蛋白酶,如胰蛋白酶和类糜蛋白酶,在介导血管新生、促进肿瘤的发展中起着重要作用。对肥大细胞的生物学特性及其特异性蛋白酶与血管新生的关系的研究,为抑制肿瘤血管新生提供新的策略。The angiogenesis refers to the formation of new blood vessels from pre-existing vascular structures,which is a dynamic process mediated by endothelial cells.This process is highly regulated by the balance between pro-angiogenic and anti-angiogenic factors in the vascular microenvironment,involving extracellular matrix proteins,adhesion molecules and proteolytic enzymes.It plays a crucial role in the cancer genesis,growth and progression of human tumors.Studies indicate that mast cell is the key host cell in the tumor infiltrate,with important consequence on tumor-associated angiogenesis and tumor growth.Activation of Mast cells releases a series of pro-angiogenic factors,in which the specific proteases,tryptase and chymase,play an important role in mediating angiogenesis and promoting tumor development.This review clarifies the biological characteristics of mast cell and the relationship between its specific proteases and angiogenesis,which provides a new therapeutic perspective for tumor angiogenesis.

关 键 词：血管新生 肥大细胞 类胰蛋白酶 类糜蛋白酶 肿瘤 

分 类 号：R730.5[医药卫生—肿瘤]