肝衰竭并发急性肾损伤热点研究新进展  

Advances in research hotspots in liver failure complicated by acute kidney injury

作　　者：庄焱[1] 谢青[1] ZHUANG Yan;XIE Qing(Department of Infectious Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院感染科,上海200025

出　　处：《临床肝胆病杂志》2018年第9期1836-1841,共6页Journal of Clinical Hepatology

基　　金：上海市公共卫生三年行动计划重点学科建设项目传染病与卫生生物学(15GWZK0102);上海申康临床技能与临床创新三年行动计划(16CR1002A);十三五科技部重大专项(2017ZX10203201-008)

摘　　要：急性肾损伤(AKI)定义为肾小球滤过率急剧下降和血清肌酐的急骤升高,是肝衰竭患者的严重并发症之一。早期诊断及处理对降低病死率、改善肝衰竭预后极为重要。对肝衰竭患者AKI的诊断标准、发病机制、生物标志物、临床特点及治疗的研究进展进行阐述。指出对AKI的定义、分期不断修正,研发高效的肾损伤生物标记物,是未来研究的方向。Acute kidney injury（AKI） is defined as a sharp drop in glomerular filtration rate（GFR） and a rapid increase in serum creatinine and is one of the most serious complications of liver failure. Early diagnosis and treatment play a vital role in reducing the mortality and improving the prognosis of liver failure. This article elaborates on the research advances in the diagnostic criteria,pathogenesis,biomarkers,clinical features,and treatment of AKI and points out that constant modification of the definition and staging of AKI and research and development of efficient biomarkers for AKI are future research directions.

关 键 词：肝功能衰竭 肾功能不全 急性 诊断 治疗学 生物学标记 

分 类 号：R575.3[医药卫生—消化系统]