幼儿血型B抗原性减弱的分析及探讨  

Analysis and discussion on the weakening of blood group B antigen in children

作　　者：杨云乐 马玲[2] 王晓卫 韩军 李亭 YANG Yunle;MA Ling;WANG Xiaowei;HAN Jun;LI Ting(Department of Clinical Laboratory,Children＇s Hospital Affiliated to Nanjing Medical University,Nanjing,210008,China;Jiangsu Blood Center Blood Transfusion Research Laboratory)

机构地区：[1]南京医科大学附属儿童医院检验科,南京210008 [2]江苏省血液中心输血研究室

出　　处：《临床血液学杂志（输血与检验）》2018年第4期626-628,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

基　　金：南京市医学科技发展项目(No:YKK17159)

摘　　要：目的:分析2例幼儿血型B抗原减弱的原因,为今后婴幼儿血型的进一步研究提供实验性数据。方法:对2017年2例13个月龄患儿血型B抗原性减弱的样本进行血清学和Sanger双碱基DNA分子测序分析。结果:2例样本其中1例ABO血型基因型为ABO*B101,另1例为Bw型。结论:本次研究提示,幼儿血型抗原减弱可能是红细胞上血型抗原表达减弱导致,血型基因并未发生突变;也有可能是由于血型亚型造成,在儿童血型鉴定时尤其要重视。Objective：To analyze the causes of the weakening of blood group B antigens in 2 children in order to provide experimental datafor further studies on the blood type of children in the future.Method：Serum and Sanger double-base DNA sequencing analysis of 2 samples of 13 children with 13 months of age in our hospital in 2017.Result：One of the two samples had an ABO blood group genotype of ABO＊B101 and the other was a Bw type.Conclusion：This study suggests that the weakening of blood group antigens in children may be caused by weakened expression of blood group antigens on red blood cells.Blood group genes have not been mutated;it may also be due to blood group subtypes,which should be valued in children＇s blood group identification.

关 键 词：儿童血型 B抗原减弱 血清学检测 基因测序 

分 类 号：R457.1[医药卫生—治疗学]