在线固相萃取-液质联用检测饮用水中9种PPCPs  

The determination method of nine trace PPCPs pollutants in drinking water by the coupling technique of the on-line solid phase extraction and liquid chromatography tandem mass spectrometry

作　　者：梁娜娜[1] 韩深[1] 王珮玥[1] 冯鑫[1] 刘萤[1] 齐鹤鸣 崔凤云[1] LIANG Na-na;HAN Shen;WANG Pei-yue;FENG Xin;LIU Ying;QI He-ming;CUI Feng-yun(Inspection and Quarantine Testing Center of Beijing Entry-Exit Inspection and Quarantine Bureau,Beijing 100026)

机构地区：[1]北京出入境检验检疫局检验检疫技术中心,北京100026

出　　处：《分析试验室》2018年第9期1029-1032,共4页Chinese Journal of Analysis Laboratory

基　　金：北京市科技计划项目(Z151100002115059)资助

摘　　要：建立了在线固相萃取-高效液相色谱质谱联用测定饮用水中克霉唑、特比萘芬、咪康唑、乙胺嗪、左旋咪唑、奥芬达唑、吡喹酮、甲苯噻嗪、溴己新等9种PPCPs污染物的方法。采用HLB柱在线富集,BEH C18进行分析检测,正离子多反应监测(M RM)模式,外标法定量。在线富集后水样中PPCPs污染物的定量限达到0.1~0.2 ng/L,线性回归方程的相关系数R2>0.99,以空白水样为基质进行的三水平加标实验的回收率范围65.0%~119.4%,相对标准偏差<10%。方法适用水样中多种PPCPs污染物高灵敏度的分析。In the present study, the determination method of 9 antifungal and anti-worm PPCPs in drinking water, including clotrimazole, terbinafine, miconazole, diethylcarbamazine, levamisole, oxfendazole, praziquantel, xylazine and bromhexine, was developed by the coupling technique of the on-line solid phase extraction （SPE） and the liquid chromatography tandem mass spectrometry. The targeted PPCPs were extracted by HLB and separated by BEH C18. The PPCPs were analyzed with positive electrospray ionization by the multiple reaction monitoring （MRM） mode. The external standard was used for quantitative analysis. The limits of quantitation of PPCPs in water samples reached 0. 1 - 0. 2 ng/L and all the correlation coefficients of the linear regression equation were R^2 〉 0.99. The recoveries of 9 PPCPs were 65.0% - 119.4% with blank water sample as the substrate. The relative standard deviations were less than 10%. Therefore, this method can satisfy the needs of high sensitive analysis of various PPCPs in water samples.

关 键 词：PPCPS 痕量检测 在线固相萃取-液相色谱串联质谱联用 

分 类 号：X830.2[环境科学与工程—环境工程]