板蓝根色胺酮金属配合物合成及与DNA切割作用研究  

Synthesis and Cleavage towards DNA of Complexes with Tryptanthrin from Isatis indigotica

作　　者：顾运琼 唐国彬[2] 覃静静 王书龙 申文英[2,3] 谭明雄 GU Yun-qiong;TANG Guo-bin;QIN Jing-jing;WANG Shu-long;SHEN Wen-ying;TAN Ming-xiong(College of Environment Science and Life,Guangxi Teachers Education University,Nanning,Guangxi,530001,China;Guangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology,Yulin Nor-mal University,Yulin,Guangxi 537000,China;Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources,Guangxi Normal University,Guilin,Guangxi,541004,China)

机构地区：[1]广西师范学院环境与生命科学学院,广西南宁530001 [2]玉林师范学院广西农产资源化学与生物技术重点实验室,广西玉林537000 [3]广西师范大学药用资源化学与药物分子工程国家重点实验室,广西桂林541004

出　　处：《时珍国医国药》2018年第7期1548-1550,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(21261025;21761033);广西高校科学技术重点项目(ZD2014108);广西高校农产品深加工与安全技术高水平创新团队及卓越学者计划(桂教人[2014]49号);广西师范大学药用资源化学与药物分子工程省部共建国家重点实验室开发课题(CMEMR2014-B08;CMEMR2017-B17);广西师范学院青年科研基金项目经费资助;广西农产资源化学与生物技术重点实验开放基金资助

摘　　要：通过溶剂热法首次合成来源板蓝根等菘蓝植物的两个色胺酮铁配合物[Fe(Try)_2]CH_3OH(1),[Fe(I-Try)_4](2),并得到晶体结构。通过琼脂凝胶电泳法,紫外可见光谱法研究表明,色胺酮铁配合物对DNA具有较强切割能力,且配合物2强于配合物1,结合常数为4.29×10~4dm^3·mol^(-1)和5.21×10~5dm^3·mol^(-1)。Two complexes [Fe（ Try）2]CH3OH（ 1）,[Fe（ I-Try）4]（ 2） of tryptanthrin from medicinal plants of Isatis indigotica were synthesized by solvothermal method for the first time,and the crystal structure was obtained. The results showed that the cleavage ability of DNA for the two complexes was improved by agarose gel electrophoresis and UV spectroscopy,and the complex2 was stronger than that of complex 1,the binding constant was 4. 29 × 10^4 dm^3 mol^-1 and 5. 21 × 10^5 dm^3 mol^（-1.

关 键 词：色胺酮 金属配合物 DNA切割作用 

分 类 号：R73-74[医药卫生—肿瘤]