黄芪建中汤联合西药治疗胃溃疡(脾胃虚寒)随机平行对照研究  

Randomized Controlled Parallel Study of Huangqi Jianzhong decoction(黄芪建中汤) combined with Western Medicine in Treating Gastric ulcer(Piwei Xuhan/脾胃虚寒)

作　　者：王创业 WANG Chuangye(Internal Medicine of Dengfeng Hospital of Traditional Chinese Medicine,Dengfeng 452470,Henan,China)

机构地区：[1]登封市中医院内科,河南登州452470

出　　处：《实用中医内科杂志》2018年第7期39-42,共4页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察黄芪建中汤联合西药治疗胃溃疡(脾胃虚寒)疗效。[方法]使用随机平行对照方法,将130例门诊患者按就诊顺序号抽签随机分为两组。对照组65例雷尼替丁,150mg/次,2次/d;枸橼酸铋钾,120mg/次,4次/d,餐前半小时口服。治疗组65例黄芪建中汤(黄芪5g,桂枝9g,白芍18g,姜~生9g,甘草6g,大枣6个,饴糖40g),水煎300mL,2次/d;呕吐清涎加姜~干、半夏,呕吐反酸加瓦楞子、乌贼骨、吴茱萸,胃脘冷痛加人参、姜~干;西药治疗同对照组。连续治疗6周为1疗程。观测临床症状、中医证候积分、复发率、幽门螺旋杆菌(Hp)、不良反应。治疗1疗程(6周),判定疗效。随访6个月,观测复发率。[结果]治疗组临床痊愈43例,显效3例,有效15例,无效4例,总有效率93.84%,对照组临床痊愈30例,显效8例,有效19例,无效8例,总有效率87.69%,临床疗效治疗组优于对照组(P<0.05);中医证候积分两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01);随访6个月,复发率治疗组6.52%低于对照组26.67%(P<0.05)。[结论]黄芪建中汤联合西药治疗胃溃疡(脾胃虚寒),明显改善临床症状,提高治疗效果,远期效果稳定,值得推广。[Objective] To observe the curative effect of Huangqi Jianzhong decoction combined with western medicine in treating gastric ulcer （Piwei Xuhan）. [Methods]Using random parallel control method, 130 outpatients were randomly divided into two groups according to the number of visits. The control group consisted of 65 cases of ranitidine, 150 mg/times, 2 times/d, bismuth potassium citrate, 120 mg/times, 4 times/d, and oral administration for half an hour before meals. In the treatment group, 65 cases of Astragalus Jianzhong （astragalus 5g, cinnamon branch 9g, paeonia lactiflora 18g, ginger 9g, licorice 6g, 6 jujube, maltose 40g）, decoction of 300mL, 2 times/d, vomiting and saliva plus dry ginger, pinellia ternata, vomit acid and corrugated, squid bone, Wuzhuyu, epigastric cold pain plus ginseng, dry ginger, and western medicine were treated with the control group. Continuous treatment for 6 weeks was the 1 course of treatment. Observation of clinical symptoms, TCM syndrome score, recurrence rate, Helicobacter pylori （Hp）, adverse reactions. The 1 course of treatment （6 weeks） was treated and the curative effect was determined. The recurrence rate was observed for 6 months. [Results] In the treatment group, 43 cases were cured, 3 cases were markedly effective, 15 cases were effective, 4 cases were invalid, the total effective rate was 93.84%. The control group was cured 30 cases, 8 cases were markedly effective, 19 eases were effective, 8 cases were invalid, the total effective rate was 87.69%, the clinical curative effect group was better than the control group （P〈0.05）; TCM syndrome score two groups all improved （P〈0.01）, The TCM syndrome integral two group all improved （P〈0.01）, treatment of TCM syndrome integral two groups were improved （P〈0.01）.The treatment group improved better than the control group （P〈0.01）; after 6 months follow-up, the recurrence rate of the treatment group was 6.52% lower than that of the control group 26.67% （P〈0.05）. [Conclusion] Huangq

关 键 词：胃溃疡 脾胃虚寒 胃痛 黄芪建中汤 雷尼替丁 枸橼酸铋钾 中医证候积分 幽门螺旋杆菌(Hp) 随访 复发率 中药复方 随机平行对照研究 

分 类 号：R573.1[医药卫生—消化系统]