不同病理性钙化类型甲状腺乳头状癌微血管密度及淋巴结转移比较研究  

Comparative study of microvessel density and lymph node metastasis in papillary thyroid carcinoma with different pathological calcifications

作　　者：王磊[1] 李海[4] 唐嘉阅 万晓洁 杨家佳[1] 程红[2] 施燕芸[2] 戚庭月[2] 杜稼苓 Wang Lei;Li Hai;Tang Jiayue;Wan Xiaojie;Yang Jiajia;Cheng Hong;Shi Yanyun;Qi Tingyue;Du Jialing(Department of Pathology,the Affiliated Hospital of Yangzhou University,Yangzhou 225009,China;Department of Pathology,Jiangsu Province Hospital,Nanjing 210029,China;Department of Ultrasound,the Affiliated Hospital of Yangzhou University,Yangzhou 225009,China;Department of Thyroid and Breast Surgery,the Affiliated Hospital of Yangzhou University,Yangzhou 225009,China)

机构地区：[1]扬州大学附属医院病理科,225009 [2]扬州大学附属医院超声科,225009 [3]扬州大学附属医院甲乳外科,225009 [4]江苏省人民医院病理学部,南京210029

出　　处：《肿瘤研究与临床》2018年第8期531-535,共5页Cancer Research and Clinic

基　　金：扬州市科技局社会发展面上项目（YZ2017085）

摘　　要：目的分析点状钙化和片状钙化甲状腺乳头状癌（PTC）的微血管密度（MVD）及淋巴结转移情况。方法选择2015年5月至2017年10月扬州大学附属医院住院手术治疗的50例PTC患者，根据术后镜下病理性钙化的不同特点分为点状钙化组（38例）和片状钙化组（12例），比较两组病例病灶中央区MVD、外周区MVD、淋巴结转移情况之间的差异。结果点状钙化组中央区、外周区平均MVD分别为（51±7）和（64±8）个/高倍视野，片状钙化组中央区、外周区平均MVD分别为（35±4）和（49±6）个/高倍视野，点状钙化组中央区、外周区MVD均高于片状钙化组，差异均有统计学意义（t=10.183、12.406，均P〈0.05）；点状钙化组颈Ⅵ区淋巴结转移率为42.1%（16/38），高于片状钙化组的8.3%（1/12），差异有统计学意义（χ2=4.635，P〈0.05）。结论不同病理性钙化类型PTC侵袭转移存在差异，伴有点状钙化的PTC较伴有片状钙化的PTC更易发生局部转移。ObjectiveTo analyze the microvessel density （MVD） and lymph node metastasis in the papillary thyroid carcinoma （PTC） with punctate or sheet calcification.MethodsFifty PTC patients in the Affiliated Hospital of Yangzhou University from May 2015 to October 2017 were retrospectively enrolled in this study. All of the 50 PTC patients were divided into punctate calcification group （38 cases） and sheet calcification group （12 cases） according to the different features of pathological calcification in microscope examination. For the two groups, the central and peripheral zone MVD and the lymph node metastasis of each PTC nodule were compared.ResultsFor PTC nodules of punctate calcification group, the mean central and peripheral zone MVD were （51±7）/HP and （64±8）/HP, respectively. For those of sheet calcification group, which were （35±5）/HP and （49±6）/HP, respectively. The mean MVD in both central and peripheral zone of PTC nodules of punctate calcification group were significantly higher than those of the sheet calcification group （t values were 10.183 and 12.406, both P 〈 0.05）. The neck Ⅵ area lymph node metastasis rates of the punctate and sheet calcification groups were 42.1% （16/38） and 8.3% （1/12）, respectively. The lymph node metastasis rate of the punctate calcification group was significantly higher than that of the sheet calcification group （χ2 = 4.635, P 〈 0.05）.ConclusionPTC nodules with different type of pathological calcification may have different invasion and metastasis, and PTC with punctate calcification is more likely to undergo local metastasis than PTC with sheet calcification.

关 键 词：甲状腺乳头状癌 钙化 微血管密度 淋巴结转移 

分 类 号：R736.1[医药卫生—肿瘤]