子宫颈神经内分泌癌35例临床病理分析  

Clinicopathological features of neuroendocrine carcinoma of the cervix： an analysis of 35 cases

作　　者：赵宏伟[1] 丁进进[3] 王丽霞[2] 孙立新[1] Zhao Hongwei;Ding Jinjin;Wang Lixia;Sun Lixin(Department of Gynaecology,Shanxi Provincial Cancer Hospital,Taiyuan 030013,China;Department of Pathology,Shanxi Provincial Cancer Hospital,Taiyuan 030013,China;Department of Obstetrics and Gynecology,the People＇ s Hospital of Linfen City,Linfen 041000,China)

机构地区：[1]山西省肿瘤医院妇科,太原030013 [2]山西省肿瘤医院病理科,太原030013 [3]山西省临汾市人民医院妇产科,041000

出　　处：《肿瘤研究与临床》2018年第8期545-547,552,共4页Cancer Research and Clinic

摘　　要：目的探讨子宫颈神经内分泌癌（NECC）患者的临床病理特征及预后相关因素。方法对山西省肿瘤医院2006年1月至2014年5月收治的35例NECC患者临床资料进行回顾性分析。结果35例NECC患者中位年龄43岁（24~64岁）；人乳头瘤病毒（HPV）18感染率为66.7%（10/15）；术前诊断准确率14.3%（5/35）。神经内分泌癌标志物Syn、CgA、AE1/AE3、P63和NSE阳性率分别为100.0%（35/35）、80.0%（28/35）、100.0%（35/35）、34.3%（12/35）和57.1%（20/35）。患者3年总生存率为34.29%（12/35），预后主要影响因素为年龄、肿瘤直径、间质浸润深度（均P〈0.05）。结论NECC单纯病理形态学检查容易误诊，联合神经内分泌癌标志物免疫组织化学检测可提高诊断准确率；HPV18在子宫颈神经内分泌癌中感染率较高；肿瘤大小是影响患者生存的主要因素之一。ObjectiveTo analyze the clinical and pathological features and prognostic factors of neuroendocrine carcinoma of the cervix （NECC）.MethodsThe clinical data of 35 cases of NECC treated in Shanxi Provincial Cancer Hospital from January 2006 to May 2014 were retrospectively analyzed.ResultsThe median age of 35 cases of NECC was 43 years old. The infection rate of human papillomavirus （HPV） 18 type was 66.7% （10/15） in 15 NECC patients who were tested with HPV. The accuracy rate of diagnosis was 14.3% （5/35） before procedure. The positive detection rate of Syn, CgA, AE1/AE3, P63 and NSE were respectively 100.0% （35/35）, 80.0% （28/35）, 100.0% （35/35）, 34.3% （12/35） and 57.1% （20/35）. The 3-year overall survival rate of 35 NECC cases was 34.29% （12/35）. The age, volume of local tumor and degrees of interstitial infiltration were the main prognostic factors of patients with NECC（all P 〈 0.05）.ConclusionsNECC is easily misdiagnosed by pathomorphological examination alone, the accuracy of diagnosis could be improved by detecting neuroendocrine carcinoma markers with immunohistochemical method. The infection rate of HPV18 is higher than the others in NECC. The volume of local tumor is one of the main prognostic factors for NECC patients.

关 键 词：子宫颈肿瘤 神经内分泌癌 预后 

分 类 号：R737.33[医药卫生—肿瘤]