解聚素-金属蛋白酶17及表皮生长因子受体在食管鳞状细胞癌中的表达及其意义  

Expressions of a disintegrin and metalloprotease 17 and epidermal growth factor recepter in esophageal squamous cell carcinoma and their significances

作　　者：岳庆峰[1] 吴莉莉 相加庆 魏祥志 汪永和[1] 张科[1] 江陈[1] Yue Qingfeng;Wu Lili;Xiang Jioqing;Wei Xiangzhi;Wang Yonghe;Zhang Ke;Jiang Chen(Department of Thoracic Surgery,the Third People＂ S Hospital of Hefei,Hefei 231281,China（Yue QF,Wei XZ,Wang YH,Zhang K,Jiang C;Department of Pathology,the Third People＇s Hospital of Hefei,Hefei 231281,China（Wu LL;Department of Thoracic Surgery,Fudan University Shanghai Cancer Center,Shanghai 200032,China（Xiang JQ)

机构地区：[1]合肥市第三人民医院胸外科,231281 [2]合肥市第三人民医院病理科,231281 [3]复旦大学附属肿瘤医院胸外科,上海200032

出　　处：《肿瘤研究与临床》2018年第7期443-446,共4页Cancer Research and Clinic

摘　　要：目的 探讨解聚素-金属蛋白酶17（ADAM17）与表皮生长因子受体（EGFR）在人食管鳞状细胞癌（ESC）组织中的表达及其与患者临床病理特征的关系.方法 选择2013年1月至2017年12月合肥市第三人民医院66例ESC患者术后病理组织石蜡标本,采用免疫组织化学法检测66例ESC组织及33例癌旁组织中ADAM17与EGFR蛋白的表达,分析二者与临床病理特征的关系,采用Kendall法分析二者表达的相关性.结果 ESC组织中ADAM17与EGFR蛋白的阳性表达率均高于癌旁组织[68.2％（45/66）比33.3％（11/33）,χ^2=10.874,P=0.001;66.7 ％（44/66）比39.4％（13/33）,χ^2=6.699,P=0.01].ADAM17蛋白、EGFR蛋白的表达与ESC病理TNM分期、浸润深度及有无淋巴结转移有关（χ^2值分别为4.797、4.890、6.089;8.790、8.766、10.154,均P＜0.05）.ADAM17蛋白的表达与EGFR蛋白表达呈正相关（rs=0.368,P＜ 0.05）.结论 ADAM17和EGFR在人ESC组织中呈高表达,且二者在肿瘤发生、发展中存在相互作用.二者联合检测可能有助于ESC转移程度的判断及预后评价.Objective To investigate the expressions of a disintegrin and metalloprotease 17 （ADAM17） and epidermal growth factor recepter （EGFR） in human esophageal squamous cell carcinoma （ESC）,and to explore their relationship with clinicopathological characteristics.Methods The paraffin specimens in postoperative pathological tissues of 66 ESC patients in the Third People＇s Hospital of Hefei from January 2013 to December 2017 were selected.Expressions of ADAM17 and EGFR proteins were examined by using immunohistochemistry in 66 cases of ESC tissues and 33 cases of adjacent tissues of the tumors.The relationship of ADAM17 and EGFR with clinicopathological features was analyzed.Kendall method was used to detect the expression correlation of ADAM17 and EGFR.Results The positive rate of ADAM17 protein in ESC tissues was higher than that in the adjacent tissues of the tumors [68.2 % （45/66） vs.33.3 % （11/33）,χ^2=10.874,P =0.001].The positive rate of EGFR protein in ESC tissues was higher than that in the adjacent tissues of the tumors [66.7 % （44/66） vs.39.4 % （13/33）,χ^2=6.699,P =0.01].The expressions of ADAM17 and EGFR protein were related with ESC pathological TNM staging,infiltration depth,lymph node metastasis （χ^2=4.797,4.890,6.089;8.790,8.766,10.154,respectively,all P 〈 0.05）.ADAM17 expression was positively correlated with EGFR protein （r,=0.368,P 〈 0.05）.Conclusions ADAM17 and EGFR are highly expressed in human ESC.Besides,ADAM17 and EGFR have the interaction in the occurrence and development of esophageal cancer.Joint detection may help to determine the degree of metastasis and evaluate prognosis.

关 键 词：食管肿瘤 解聚素-金属蛋白酶17 受体 表皮生长因子 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]