中药联合放射治疗中晚期食管癌预后因素分析  

Traditional Chinese medicine combined with radiotherapy for treatment of middle and advanced esophageal neoplasms： an analysis of prognostic factors

作　　者：王玉强[1] 张永红[1] 李绵 耿惠[1] 郭秋峰 路洪超[2] 齐增平[1] Wang Yuqiang;Zhang Yonghong;Li Mian;Geng Hui;Guo Qiufeng;Lu Hongchao;Qi Zengping(Department of Medical Oncology,Civil Administration Hospital of Hebei Province,Xingtai 054000,China（Wang YQ,Zhang YH,Geng H,Qi ZP;Department of Radiation,Civil Administration Hospital of Hebei Province,Xingtai 054000,China（Li M,Guo QF,Lu HC)

机构地区：[1]河北省民政总医院肿瘤内科,邢台054000 [2]河北省民政总医院放疗科,邢台054000

出　　处：《肿瘤研究与临床》2018年第7期464-467,共4页Cancer Research and Clinic

基　　金：河北省科学技术研究与发展计划（162777275）

摘　　要：目的 探索影响中药联合放射治疗中晚期食管癌患者的预后因素.方法 对2009年3月至2012年3月在河北省民政总医院接受中药联合放射治疗的462例食管癌患者进行回顾性分析.采用寿命表计算患者总体中位生存时间及1、3、5年生存率,单因素分析用Log-rank法,多因素分析用Cox比例风险模型.结果 462例食管癌患者中位生存时间24.2个月（12.9～36.6个月）,1、3、5年生存率分别为80.3％、30.6％和10.5％.单因素分析结果显示,年龄（χ^2=89.773,P=0.000）、肿瘤直径（χ^2=102.373,P=0.000）、临床分期（χ^2=128.903,P=0.000）、合并其他疾病（χ^2=65.366,P=0.000）及近期疗效（χ^2=64.948,P=0.000）与中药联合放射治疗中晚期食管癌预后有关.多因素分析结果显示,年龄（RR=1.625,95％CI 1.251～2.111,P=0.000）、临床分期（RR=2.437,95％CI 1.874～3.168,P=0.000）、合并其他疾病（RR=1.628,95％CI 1.278～ 2.076,P=0.000）及近期疗效（RR=1.865,95％CI1.594～2.182,P=0.000）是影响中药联合放射治疗中晚期食管癌预后的独立因素.结论 老年患者、Ⅲ期食管癌、合并其他疾病及近期疗效较差影响中药联合放射治疗中晚期食管癌患者的预后.Objective To explore the prognostic factors of middle and advanced esophageal neoplasms treated by traditional Chinese medicine combined with radiotherapy.Methods A total of 462 esophageal neoplasms patients treated by traditional Chinese medicine combined with radiotherapy from March 2009 to March 2012 in Civil Administration Hospital of Hebei Province were retrospectively analyzed.The overall median survival time and the survival rate of 1,3 and 5 years were calculated by using life table.Log-rank test was used for single-factor analysis and Cox model was used for multiple-factor analysis.Results The median survival time of 462 esophageal neoplasm patients was 24.2 months （12.9-36.6 months）.The survival rate of 1,3 and 5 years was 80.3 %,30.6 % and 10.5 % respectively.Single-factor analysis showed that the age （x^2 =89.773,P =0.000）,tumor diameter （x^2 =102.373,P =0.000）,clinical staging （x^2 =128.903,P =0.000）,concomitant with other diseases （x^2 =65.366,P =0.000） and the short term effect （x^2 =64.948,P =0.000） were associated with prognosis of middle and advanced esophageal neoplasms treated by traditional Chinese medicine combined with radiotherapy.Multiple-factor analysis showed that the age （RR =1.625,95 % CI 1.251-2.111,P=0.000）,clinical staging （RR =2.437,95 % CI 1.874-3.168,P=0.000）,concomitant with other diseases （RR =1.1.628,95 % CI 1.278-2.076,P =0.000） and the short term effect（RR =1.865,95 % CI 1.594-2.182,P =0.000） were the independent prognosis factors for middle and advanced esophageal neoplasms treated by traditional Chinese medicine combined with radiotherapy.Conclusion Elderly patients,esophageal neoplasms in stage Ⅲ,concomitant with other diseases and poor short-term effect could influence the prognosis of the patients with middle and advanced esophageal neoplasms treated by traditional Chinese medicine combined with radiotherapy.

关 键 词：食管肿瘤 医学 中国传统 中草药 放射疗法 计算机辅助 预后 危险因素 

分 类 号：R735.1[医药卫生—肿瘤]