抗菌肽鲎素的研究进展  

Research Progresses on Antimicrobial Peptide Tachyplesins

作　　者：李寒梅 唐勇军 王顺启[1] 代建国[2] LI Han-mei;TANG Yong-jun;WANG Shun-qi;DAI Jian-guo(School of Life Sciences,Nanchang University,Nanchang 330031,Jiangxi,China;School of Applied Chemistry and Bioteehnology,Shenzhen Polytechnic,Shenzhen 518000,Guangdong,China)

机构地区：[1]南昌大学生命科学学院,中国江西南昌330031 [2]深圳职业技术学院应用化学与生物技术学院,中国广东深圳518000

出　　处：《生命科学研究》2018年第4期338-344,共7页Life Science Research

基　　金：广东省自然科学基础研究重大项目(2017GKZDXM011);广东省高校高层次人才项目(20132011);国家自然科学基金地区科学基金资助项目(31460260)

摘　　要：已报道的抗菌肽鲎素(tachyplesins,TPs)共分5种,均由鲎血细胞分离产生,是鲎先天免疫系统的重要功能物质,为鲎机体抵抗病原物入侵提供天然防御屏障。近30年的研究表明,TPs抗菌肽显示出广谱生物活性、较低正常细胞毒性、不易产生微生物抗性等特点,作为一种全新型的肽类药物备受关注。文中主要从TPs的分子结构,对微生物、藻类细胞、肿瘤细胞及一些病毒的抑杀活性,作用机制,以及工程表达情况等方面进行介绍,综述TPs的应用前景,并对当前研究瓶颈进行评述。Antibacterial peptides tachyplesins（TPs）, isolated from the hemocytes of horseshoe crabs and divid-ed into five kinds, play an important role in immunological function in the limulus immune system and pro-vide a natural defense barrier for the invasion of pathogens. Nearly 30 years of research shows that TPs ex-hibit broad-spectrum bioactivities, low cytotoxicity toward normal cells, and low levels of acquired resistance in microbes. As an entirely new type of peptide drug, TPs have become an intensely studied topic. Herein,the molecular structure of TPs, bioactivity against all kinds of microorganisms and tumor cells, action mech-anisms and engineering expression are introduced. The application and the bottleneck of current research of TPs are also described.

关 键 词：抗菌肽鲎素(TPs) 生物活性 作用机制 基因工程 应用 瓶颈 

分 类 号：Q74[生物学—分子生物学]