艾司西酞普兰联合电刺激厌恶疗法对难治性强迫症31例临床观察  

Clinical Efficacy of Escitalopram Combined with Electrical Stimulation Aversion Therapy on Refractory Obsessive-compulsive Disorder： 31 Cases of Clinical Report

作　　者：郑琳 田悦 程奥博 芦珊 郭淑英 ZHENG Lin;TIAN Yue;CHENG AO-bo(Kailuan Mental Health Center Affiliated to North China University of Science and Technology,Tangshan 06300)

机构地区：[1]华北理工大学附属开滦精神卫生中心中西医结合病区,河北唐山063000

出　　处：《医学临床研究》2018年第8期1542-1545,共4页Journal of Clinical Research

摘　　要：[目的]探讨艾司西酞普兰联合电刺激厌恶疗法对难治性强迫症的临床疗效.[方法]选取2017年1月至2018年1月期间在本院住院治疗的62例难治性强迫症患者作为研究对象,按照简单随机法分为两组,各组31例患者.对照组予以艾司西酞普兰治疗,观察组予以艾司西酞普兰联合电刺激厌恶疗法治疗.比较两组患者治疗效果,治疗前后Yale-Brown强迫量表、HAMA量表评分以及治疗期间不良反应发生情况.[结果]观察组治疗有效率为93.55％,对照组治疗有效率为74.29％,观察组患者治疗有效率高于对照组（P〈0.05）.两组患者治疗后Yale-Brown强迫量表、HAMA量表评分均低于治疗前（P〈0.05）,且观察组患者治疗后Yale-Brown强迫量表评分低于对照组（P〈0.05）;两组患者治疗后HAMA量表评分和不良反应发生率比较差异无统计学意义（均P〉0.05）.[结论]艾司西酞普兰联合电刺激厌恶疗法治疗难治性强迫症效果显著,可有效改善患者临床症状,且安全性较高.[Objective]To investigate the effect of escitalopram combined with electrical stimulation aversion therapy on refractory obsessive-compulsive disorder. [Methods]From January 2017 to January 2018, 62 cases of patients with refractory obsessive-compulsive disorder were studied in our hospital. According to the simple random method, they were divided into two groups, 31 cases in each group, the control group was treated with escitalopram, and the observation group was treated with escitalopram combined with electric stimulation aversion therapy. The therapeutic effects, the Yale-Brown compulsion scale, HAMA scale score, and the incidence of adverse reactions during treatment were compared between the two groups. [Results] The effective rate of the control group was 74.29%, the effective rate of the observation group was 93.55%, and the effective rate of the observation group was higher than that of the control group （ P〈0.05）. The scores of the Yale-Brown and HAMA scales in the two groups were lower than those before the treatment （ P 〈0.05）, and the score of the Yale-Brown compulsion scale in the observation group was lower than that of the control group （ P〈0.05）, and there was no statistical difference between the two groups after the treatment （ P 〉0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （ P〉 0.05）. [Conclusion]Escitalopram combined with electrical aversion therapy is effective in treating obsessive- comoulsive disorder. It can effectively improve the clinical symptoms of patients with high safety.

关 键 词：强迫性人格障碍/治疗 药用制剂 电刺激疗法 

分 类 号：R749.75[医药卫生—神经病学与精神病学]