血清OPG/RANKL比例与脑梗死病因亚型关系的研究  

Relationship between serum OPG/RANKL and cerebral infarction subtypes

作　　者：宫青 赵洪芹[1] Gong Qing;Zhao Hongqin(Department of Neurology,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266071;Department of Neurology,Weihai Wendeng District People＇s Hospital,Weihai,Shandong 264000 2.Department of Neurology,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266071)

机构地区：[1]山东省青岛大学附属医院神经内科,山东青岛266071 [2]山东省威海市文登区人民医院神经内科,山东威海264000

出　　处：《中外女性健康研究》2018年第18期23-25,共3页Women＇s Health Research

摘　　要：目的:探讨脑梗死患者血清中的骨保素(OPG)/核因子kappa B受体活化因子配体(RANKL)比例与脑梗死病因亚型关系。方法:选取2016年2月至2018年1月青岛大学医学院附属医院神经内科住院的急性脑梗死患者中的157例,根据TOAST分型分为大动脉粥样硬化性脑梗死(LAA)和小动脉闭塞性脑梗死(SAO)两组,另外选取100例健康体检者作为对照组。采用酶联免疫吸附法(ELISA)分别检测三组血清中的OPG、RANKL水平,计算OPG/RANKL比例并比较;将同一病因亚型根据患者梗死体积分为大梗死组、中梗死组和小梗死组,比较三组血清中的OPG、RANKL水平及OPG/RANKL比例。结果:LAA组血清中OPG水平、OPG/RANKL比例均明显高于SAO组和对照组,LAA组血清中RANKL水平均明显低于SAO组和对照组,SAO组OPG/RANKL比例亦明显高于对照组,其差异均具有统计学意义(P<0.05)。在LAA中,大梗死组患者血清中OPG水平、OPG/RANKL比例均明显高于中梗死组和小梗死组,RANKL水平则明显低于中梗死组和小梗死组,中梗死组患者血清中OPG水平、OPG/RANKL比例均明显高于小梗死组,RANKL水平则明显低于小梗死组,其差异均具有统计学意义(P <0.05)。在SAO中,大梗死组SAO患者血清中OPG水平、OPG/RANKL比例均明显高于中梗死组和小梗死组,RANKL则明显低于梗死组和小梗死组;中梗死组SAO患者OPG/RANKL比例明显高于小梗死组,其差异均具有统计学意义(P <0.05)。结论:脑梗死患者血清中OPG/RANKL比例在LAA、SAO病因亚型患者中均随患者病情严重程度而增高,且不同病因亚型的OPG/RANKL比例存在明显差异,也许能够通过检测脑梗死患者血清中OPG、RANKL水平,计算OPG/RANKL比例判断其病情的严重程度。Objective： To explore the relationship between the proportion of OPG/kappa B receptor activating factor ligand （RANKL） in the serum of cerebral infarction and the subtype of cerebral infarction. Methods： From February 2016 to January 2018, 157 patients with acute cerebral infarction admitted in the neurology department of hospital were divided into two groups： large atherosclerotic cerebral infarction （LAA） and arteriolo occlusive cerebral infarction （SAO）. In addition, 100 pa tients were selected as the control group. The levels of OPG and RANKL in three groups of serum were detected by enzyme linked immunosorbent assay （ELISA）, and the proportion of OPG/RANKL was calculated and compared. The same disease type was divided into large infarction group, middle infarction group and small infarction group according to the infarct volume. The OPG, RANKL level and OPG/RANKL ratio in the serum of the three groups were compared. Results： the serum level of OPG and OPG/RANKL in serum of LAA group were significantly higher ihan that in group SAO and control group. The level of RANKL in serum of LAA group was significantly lower than that of group SAO and control group, and the proportion of OPG/RANKL in SAO group was significantly higher than that in control group, and the difference was statistically significant （P 〈 0. 05）. In LAA, the level of OPG and OPG/RANKL in the serum of the large infarct group were significantly higher than that of the middle infarction group and the small infarction group. The level of RANKL was significantly lower than that in the middle and small infarct groups. The level of OPG and the OPG/RANKL in the serum of the patients in the middle in farct group were significantly higher than those in the small infarction group, and the RANKL level was significantly lower than that of the small infarction group. All of them were statislically significant （P 〈 0. 05）. In SAO, the serum levels of OPG and OPG/RANKL in the patients with SAO in the large infarct group wer

关 键 词：大动脉粥样硬化性脑梗死 小动脉闭塞性脑梗死 NIHSS评分 

分 类 号：R743.33[医药卫生—神经病学与精神病学]