叶酸和替普瑞酮联合三联疗法对老年Hp阳性慢性萎缩性胃炎患者血清G-17、PG及免疫功能的影响  

Effects of Folic Acid and Teprenone Combined with Triple Therapy on Serum G-17,PG and Immune Function in Hp-positive Elderly Patients with Chronic Atrophic Gastritis

作　　者：贺亚妮[1] 安毅[1] 穆亚娟 李飞飞 HE Ya-ni;AN Yi;MU Ya-juan;LI Fei-fei(Department of Digestive System Diseases,the First Hospital of Yulin,Yulin,Shaanxi 719000,China)

机构地区：[1]榆林市第一医院消化内科,陕西榆林719000

出　　处：《解放军医药杂志》2018年第9期89-92,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：陕西省卫生厅科研基金项目(2014JM32541)

摘　　要：目的观察叶酸和替普瑞酮联合三联疗法对老年幽门螺杆菌(Hp)阳性慢性萎缩性胃炎(CAG)患者血清胃泌素-17(G-17)、胃蛋白酶原(PG)及免疫功能的影响。方法选取2015年6月—2017年9月治疗的64例老年Hp阳性CAG患者。按照治疗方法的不同分为观察组与对照组,每组32例。对照组给予三联疗法联合叶酸治疗,观察组在对照组基础上给予替普瑞酮治疗。比较两组的临床疗效,比较治疗前后的胃镜病理积分、血清G-17、PG和免疫功能,并记录并发症发生情况。结果观察组总有效率高于对照组(P<0.01)。治疗后,两组的CD4+、CD4+/CD8+以及血清G-17和PGⅠ水平均高于治疗前,观察组高于对照组(P<0.05)。治疗后,两组的各项胃镜病理积分、CD8+和血清PGⅡ水平低于治疗前,观察组低于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论叶酸和替普瑞酮联合三联疗法对老年Hp阳性CAG的临床疗效显著,安全性较好。Objective To observe effects of Folic Acid and Teprenone combined with triple therapy on serum gastrin-17 （G-17）, pepsinogen （PG） and immune function in helicobacter pylori （Hp）-positive elderly patients with chronic atrophic gastritis （CAG）. Methods A total of 64 Hp-positive elderly patients with CAG during June 2015 and September 2017 were divided into observation group and control group （ n =32 for each group） according to different treatment methods. Control group was treated with triple therapy combined with Folic Acid, while observation group was added with Teprenone on the basis of treatment for control group. In two groups, clinical effect, pathological scores of gastroscopy, serum G-17, PG and immune function before and after treatment were compared, and incidence rate of complications were recorded. Results The total effective rate in observation group was higher than that in control group （ P 〈 0.01）. After treatment, levels of CD4＋, CD4＋/CD8＋ and serum G-17 and PG I were higher than those before treatment in two groups, and the levels in observation group were higher than those in control group （ P 〈0.05）; pathological scores of gastroscopy, CD8＋ and serum PG II levels were lower than those before treatment in two groups, and the levels in observation group were significantly lower than those in control group （ P 〈0.05）. There was no significant difference in incidence rate of adverse reactions between two groups （ P 〉0.05）. Conclusion Folic Acid and Teprenone combined with triple therapy in treatment of helicobacter pylori （Hp）-positive elderly patients with chronic atrophic gastritis may achieve good clinical effect and safety.

关 键 词：叶酸 替普瑞酮 幽门螺杆菌 胃炎 萎缩性 胃泌素-17 胃蛋白酶原 

分 类 号：R573.32[医药卫生—消化系统]